Author: Yang, Dao Title: Antimicrobial Packaging Films: Encapsulation of Allyl-Isothiocyanate in βCyclodextrin The accompanying research report is submitted to the University of Wisconsin-Stout, Graduate School in partial completion of the requirements for the Graduate Degree/ Major: MS Manufacturing Engineering Research Advisor: Joongmin Shin, Ph.D. Submission Term/Year: Spring, 2013 Number of...

Article history: Received on: 26/07/2015 Revised on: 15/08/2015 Accepted on: 09/09/2015 Available online: 27/09/2015 Objective To evaluate the effect of Polyethylene glycol and β-cyclodextrin on the solubility and dissolution of silymarin, a poorly water soluble herbal drug. Methodology Effects of beta cyclodextrins and Polyethylene glycol on solubility of silymarin were evaluated by phase solu...

The solid state properties and dissolution behavior of lamotrigine in its inclusion complex with βCyclodextrin were investigated.Preformulation study of lamotrigine was carried out. Dialysis study of lamotrigine with β-Cyclodextrin in pretreated dialysis bags showed that lamotrigine binds with βCyclodextrin in the ratio of 1:2. Solid dispersions were prepared by kneading and spray dried method....

In the present study Rizatriptan benzoate, which is the bitter drug requires taste, masking. βCyclodextrin is used in taste masking, which improves the patient compliance and also increases the rate of dissolution. Solid dispersion of drug and βCyclodextrin were prepared which was optimised in 1: 8 ratios, which gave satisfactory results for taste masking. This was then characterised using Diff...

Antimycotic bifonazole (BIF) is a very hydrophobic compound, which is a major drawback for obtaining topical pharmaceutical formulations with optimal bioavailabiliy and for the penetration into hydrophilic human nail matrices. Cyclodextrins may increase local drug delivery by enhancing the drug release and/or permeation. The binary systems between bifonazole and β-cyclodextrin were prepared in ...

This study aims to prove the complexation of cefpodoxime proxetil (CP) by hydroxypropyl-βcyclodextrin (HP-βCD) in the presence of sodium carboxymethyl cellulose (Na CMC), and investigates the permeability of CP in the complexes. The CP–HP-β-CD complex was prepared by kneading method and was characterized by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR) and D...

The applicability of micellar electrokinetic capillary chromatography (MEKC) for the separation of benzodiazepine (BZD) derivates with different structural characteristics has been studied. Efforts were first focused on the optimization of the analytical conditions, on the effects of buffer concentration, surfactant concentration and buffer pH on the separation. To manipulate selectivity of the...

The objective of the present study was to formulate and evaluate nasal delivery system contains Ondansetron hydrochloride 4 mg/ml. Ondansetron hydrochloride loaded colloidal dispersion were prepared for nasal drug delivery using various polymers like β-cyclodextrin, hydroxyl propyl βcyclodextrin at different concentrations. The optimized formulation contains 0.02% benzalkonium chloride as a pre...

Purpose: To improve the aqueous solubility of phloridzin by complexing it with hydroxypropyl-βcyclodextrin (HP-β-CD). Methods: The complex of phloridzin with HP-β-CD was prepared by freeze-drying method. The physicochemical properties of the complex were investigated by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), differential scanning calorimetry (DSC) and x-ray diffracto...