Beta-glucuronidase (βG) is a potential biomarker for cancer diagnosis and prodrug therapy. The ability to image βG activity in patients would assist in personalized glucuronide prodrug cancer therapy. However, whole-body imaging of βG activity for medical usage is not yet available. Here, we developed a radioactive βG activity-based trapping probe for positron emission tomography (PET). We gene...

The present study was carried out to evaluate the specific and amplified β-glucuronidase (βG) expression in prostate cancer cells by using a prostate‑specific antigen (PSA) promoter-controlled bicistronic adenovirus and to evaluate the specific killing of prostate cancer cells after the application of the prodrug DOX‑GA3. Bicistronic adenoviral expression vectors were constructed, and the effec...

Two main classes of interaction between soluble dietary fibres (SDFs), such as (1,3:1,4)-β-D-glucan (βG) and arabinoxylan (AX) and bile salt (BS) or diluted porcine bile, were identified by (13)C NMR and small angle X-ray scattering (SAXS). Small chemical shift differences of BS NMR resonances were consistent with effective local concentration or dilution of BS micelles mostly by βG, suggesting...

The Stone-Čech compactification of discrete semigroups is a tool of central importance in several areas of mathematics, and has been studied extensively. We think of the Stone-Čech compactification of a discrete abelian semigroup G as the set βG of ultrafilters on G, where the point x ∈ G is identified with the principal ultrafilter {A ⊆ G ∣∣x ∈ A}, and the basic open sets are those of the form...

PURPOSE To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth g...

We consider the problem of counting simultaneous conjugacy classes n-tuples in a finite group G. Let αG,n denote number n-tuples, and βG,n commuting study generating functions AG(t)=∑n≥0αG,ntn, BG(t)=∑n≥0βG,ntn, which are rational t. show that AG(t) determines is completely determined by class equation prove normalized AG(t/|G|) BG(t/|G|) invariants isoclinism families. compute exponential grow...

Hematology and blood cells from 4 adult common palm civets (Paradoxurus hermaphroditus) in Khaokeaw Open Zoo were prepared for morphology, cytochemistry and ultrastructure observations. There was no blood parasite in all civets. The red blood cells showed relatively uniform in size, with 4.3 μm mean diameter. Neutrophils had tight constricted, multilobed nuclei and contained many specific granu...

Bread and tea are usually consumed separately, but there may be different food-matrix interactions and changes in starch characteristics when they are combined in bread. This study developed breads (white bread, WF; black tea, BT; beta glucan, βG; beta glucan plus black tea, βGBT) and determined their starch functionalities. Breads were developed using a standard baking recipe and determined th...

Enzyme prodrug therapy has the potential to remedy the lack of selectivity associated with the systemic administration of chemotherapy. However, most current systems are immunogenic and constrained to a monotherapeutic approach. We developed a new class of fusion proteins centered about the human enzyme β-glucuronidase (βG), capable of converting several innocuous prodrugs into chemotherapeutic...

Within the context of massive N -component φ scalar field theory, we use asymptotic Padéapproximant methods to estimate from prior orders of perturbation theory the five-loop contributions to the coupling-constant β-function βg, the anomalous mass dimension γm, the vacuum-energy βfunction βv, and the anomalous dimension γ2 of the scalar field propagator. These estimates are then compared with e...