leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action. the reducing effect of α2-adrenoceptors inhibition on body weight and appetite and also enhancing effects on lipolysis, sympathetic activation and plasma insulin levels in animals have been reported. we studied the effect of yohimbine treatment (2 mg...

Suppose that α1,α2,β1,β2∈ℝ. Let α1,α2>1 be irrational and of finite type such 1,α1−1,α2−1 are linearly independent over ℚ. c a real number in the range 1<c<12∕11. In this paper, it is proved there exist infinitely many primes intersection Beatty sequences ℬα1,β1=⌊α1n+β1⌋, ℬα2,β2=⌊α2n+β2⌋ Piatetski-Shapiro sequence

Previous reports demonstrate that the α2-integrin (α2) mediates pancreatic ductal adenocarcinoma (PDAC) cell interactions with collagens. We found that while well-differentiated cells use α2 exclusively to adhere and migrate on collagenI, poorly differentiated PDAC cells demonstrate reduced reliance on, or complete loss of, α2. Since well-differentiated PDAC lines exhibit reduced in vitro invas...

BACKGROUND We have shown that the ouabain-sensitive α2 Na,K-ATPase is required for adrenocorticotropic hormone (ACTH)-induced hypertension and gestational blood pressure regulation. It is therefore of interest to explore whether this binding site participates in the development of other forms of hypertension, such as deoxycorticosterone acetate (DOCA)-salt using mutant mice with altered sensiti...

Dexmedetomidine, a potent α2-adrenoceptor (α2-AR) agonist, is extensively used in the operating room (OR) and intensive care unit (ICU) has been applied for treatment of several diseases. Western blotting routinely to investigate protein levels α-adrenergic receptor (α-AR), apoptosis related proteins (Bcl-2, Bax Cleaved Caspase 3) range associated with Nrf2/ARE pathway (Nrf2, HO-1, NQO-1, SOD) ...

We investigated the expression of salivary α2-macroglobulin (α2-MG) in patients with type 2 diabetes mellitus (T2DM) to investigate its value for predicting damage to the salivary glands. A total of 116 patients with T2DM and 60 patients with impaired fasting glucose (IFG) were included in this study. Sixty health volunteers were enrolled as a control group. Unstimulated saliva was collected at...

α2-アンチプラスミン（α2-antiplasmin: α2-AP）は線溶反応の重要な制御因子で，プラスミン活性を阻害するとともに，プラスミノゲンのフィブリンへの集積を抑制することでプラスミン産生も抑制する．α2-APはC端及びN端の翻訳後修飾をそれぞれ受け，4種類の分子種から構成される．α2-APの測定法は，合成基質を用いて残存プラスミン活性を測定する方法であり，即時反応性のプラスミン不活化能を測定するものであるため，全ての分子種のプラスミン阻害能を測定しているものではない．またプラスミノゲンのフィブリン集積抑制効果に対しても十分には反映されているものではない．α2-APが低下している病態では出血傾向を呈するが，先天的に低下している場合と，後天的に低下している場合がある．後天的な低下は肝合成能低下の場合と，線溶活性化に伴う消費性の低下がある．一方，炎症性疾患においてはα2-APは上...

The yeast transcription factor MATα2 (α2) is a short-lived protein known to be ubiquitylated by two distinct pathways, one involving the ubiquitin-conjugating enzymes (E2s) Ubc6 and Ubc7 and the ubiquitin ligase (E3) Doa10 and the other operating with the E2 Ubc4 and the heterodimeric E3 Slx5/Slx8. Although Slx5/Slx8 is a small ubiquitin-like modifier (SUMO)-targeted ubiquitin ligase (STUbL), i...

BACKGROUND The cardiotonic steroid/ouabain-binding site of the α subunit of Na,K-ATPase is thought to play an important role in cardiovascular homeostasis. Previously, we demonstrated the cardiotonic steroid-binding site of the α2 Na,K-ATPase is involved in adrenocorticotropic hormone (ACTH)-induced hypertension by using gene-modified α2(R/R) mice in which the cardiotonic steroid-binding site i...