نتایج جستجو برای: α1 receptor
تعداد نتایج: 594913 فیلتر نتایج به سال:
introduction: neurons in layer ii and iii of the somatosensory cortex in rats show high frequency (33 ± 13 hz) of miniature excitatory postsynaptic currents (mepscs) that their rates and amplitudes are independent of sodium channels. there are some changes in these currents in neurodegenerative and psychological disorders. regarding to well known roles of the neuromodulatory brain systems in th...
In this study the effect of adrenergic receptor agonists and antagonists on physostigmine induced yawning was investigated. Intraperitoneal injection of different doses of physostigmine (0.03, 0.05, 0.1 and 0.2 mg/kg) caused yawning in white rats. The greatest response was seen at a dose of 0.2 mg/kg physostigmine. Phenylephrine, an α1 agonist, and clonidine, an α2 agonist, led to a decrease in...
Alzheimer disease features amyloid-β (Aβ) peptide deposition in brain and blood vessels and is associated with hypertension. Aβ peptide can cause vasoconstriction and endothelial dysfunction. We observed that Aβ peptides exert a chronotropic effect in neonatal cardiomyocytes, similar to α1-adrenergic receptor autoantibodies that we described earlier. Recently, it was shown that α1-adrenergic re...
Hypothesis / aims of study It is clinically known that anticholinergic agents, commonly used for treating overactive bladder, etc., act on the muscarinic receptor in salivary glands, causing dry mouth as an adverse effect. Not only the muscarinic receptor but also the α1-adrenergic receptor are present in human salivary glands, and are thought to accelerate saliva production. The common adverse...
The involvement of supraspinal alpha-adrenergic receptors in tonic pain was assessed in formalin-induced pain in rats. The alpha2 adrenoceptor agonist clonidine, along with yohimbine and prazosin, α2 and α1 receptor antagonists, were introduced intracerebroventrically (icv) and/or systemically in different doses. The data show that 1) clonidine exerts an alpha adrenergic analgesic effect, ...
BACKGROUND The immune system plays a pivotal role in myocardial homeostasis and response to injury. Interleukins-4 and -13 are anti-inflammatory type-2 cytokines, signaling via the common interleukin-13 receptor α1 chain and the type-2 interleukin-4 receptor. The role of interleukin-13 receptor α1 in the heart is unknown. METHODS AND RESULTS We analyzed myocardial samples from human donors (n...
We describe the expression of the extracellular domain of the human α1 nicotinic acetylcholine receptor (nAChR) in lepidopteran insect cells (i-α1-ECD) and its suitability for use in antigen-specific therapies for Myasthenia Gravis (MG). Compared to the previously expressed protein in P. pastoris (y-α1-ECD), i-α1-ECD had a 2-fold increased expression yield, bound anti-nAChR monoclonal antibodie...
Zolpidem is not a typical GABAA receptor hypnotic. Unlike benzodiazepines, zolpidem modulates tonic GABA currents in the rat dorsal motor nucleus of the vagus, exhibits residual effects in mice lacking the benzodiazepine binding site, and improves speech, cognitive and motor function in human patients with severe brain injury. The receptor by which zolpidem mediates these effects is not known. ...
Binge drinking, frequently referred to clinically as problem or hazardous drinking, is a pattern of excessive alcohol intake characterized by blood alcohol levels ≥0.08 g% within a 2-h period. Here, we show that overexpression of α1 subunits of the GABA(A) receptor contributes to binge drinking, and further document that this involvement is related to the neuroanatomical localization of α1 rece...
the involvement of supraspinal alpha-adrenergic receptors in tonic pain was assessed in formalin-induced pain in rats. the alpha2 adrenoceptor agonist clonidine, along with yohimbine and prazosin, α2 and α1 receptor antagonists, were introduced intracerebroventrically (icv) and/or systemically in different doses. the data show that 1) clonidine exerts an alpha adrenergic analgesic effect, in ad...
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