Introduction: α1-antitrypsin deficiency (α1-ATD) is one of the most common genetic disorders in white race, a usual cause of liver disease in children, and hepatopulmonary involvement in children and adult. The aim of this case description is presenting a child with early lung disease without liver parenchymal disorder. Case presentation: We describe a 13 year old boy because of exertional dysp...

The Alexandrov–Fenchel inequality bounds from below the square of mixed volume V(K1,K2,K3,…,Kn) convex bodies K1,…,Kn in ℝn by product volumes V(K1,K1,K3,…,Kn) and V(K2,K2,K3,…,Kn). As a consequence, for integers α1,…,αm∈ℕ with α1+⋯+αm=n Vn(K1)α1n⋯Vn(Km)αmn suitable powers Vn(Ki) Ki, i=1,…,m, is lower bound V(K1[α1],…,Km[αm]), where αi multiplicity which Ki appears volume. It has been conjectur...

Suppose that α1,α2,β1,β2∈ℝ. Let α1,α2>1 be irrational and of finite type such 1,α1−1,α2−1 are linearly independent over ℚ. c a real number in the range 1<c<12∕11. In this paper, it is proved there exist infinitely many primes intersection Beatty sequences ℬα1,β1=⌊α1n+β1⌋, ℬα2,β2=⌊α2n+β2⌋ Piatetski-Shapiro sequence

This is a report of novel variant the α1-globin gene—(α1) α51 Gly &gt; Cys (CE9), c.154 GGC TGC, named Hb Mazandaran, which was observed in an Iranian family. gives rise to previously undescribed haemoglobin that undetectable by capillary electrophoresis (CE). detected two cases combination with β-globin mutation, and it does not seem be associated severe haematological abnormalities carriers.

We have previously identified the scaffold protein liprin-α1 as an important regulator of integrin-mediated cell motility and tumor cell invasion. Liprin-α1 may interact with different proteins, and the functional significance of these interactions in the regulation of cell motility is poorly known. Here we have addressed the involvement of the liprin-α1 partner GIT1 in liprin-α1-mediated effec...

Ca2+ channels are voltage-gated ion present in the membrane of most excitable cells. The nomenclature for Ca2+channels was proposed by [131] and approved NC-IUPHAR Subcommittee on [72]. Most form hetero-oligomeric complexes. α1 subunit is pore-forming provides binding site(s) practically all agonists antagonists. 10 cloned α1-subunits can be grouped into three families: (1) high-voltage activat...

How conformational signals initiated from one end of the integrin are transmitted to the other end remains elusive. At the ligand-binding βI domain, the α1/α1'-helix changes from a bent to a straightened α-helical conformation upon integrin headpiece opening. We demonstrated that a conserved glycine at the α1/α1' junction is crucial for maintaining the bent conformation of the α1/α1'-helix in t...

introduction: neurons in layer ii and iii of the somatosensory cortex in rats show high frequency (33 ± 13 hz) of miniature excitatory postsynaptic currents (mepscs) that their rates and amplitudes are independent of sodium channels. there are some changes in these currents in neurodegenerative and psychological disorders. regarding to well known roles of the neuromodulatory brain systems in th...

introduction: α1-antitrypsin deficiency (α1-atd) is one of the most common genetic disorders in white race, a usual cause of liver disease in children, and hepatopulmonary involvement in children and adult. the aim of this case description is presenting a child with early lung disease without liver parenchymal disorder. case presentation: we describe a 13 year old boy because of exertional dysp...

Importin α1 is involved in nuclear import as a receptor for proteins with a classical nuclear localization signal (cNLS). Here, we report that importin α1 is localized to the cell surface in several cancer cell lines and detected in their cultured medium. We also found that exogenously added importin α1 is associated with the cell membrane via interaction with heparan sulfate. Furthermore, we r...