Diverse α-naphthylamine derivatives were easily prepared from corresponding aldimines derived from commercially available α-naphthaldehyde and anilines or isomeric pyridinecarboxyaldehydes and α-naphthylamine. The secondary amines obtained were tested as possible antifungal and cytotoxic agents. The diverse N-aryl-N-[1-(1-naphthyl)but-3-enyl]amines obtained were active (IC(50) < 10 μg/mL) again...

Af-Hydroxy-2-naphthylamine produced bladder tumors in three of four dogs when administered over a period of 30 months (dogs were sacrificed 15 months later) in dimethyl sulfoxide solution by repeated instillation directly into the bladders. ./V-Hydroxy-1-naphthylamine was more carcinogenic than TV-hydroxy^-naphthylamine by administration to rats, but the reverse was observed in four experiments...