BACKGROUND Type I hypersensitivity is an allergic reaction characterized by the overactivity of the immune system provoked by normally harmless substances. Glucocorticoids, anti-histamines, or mast cell stabilizers are the choices of treatment for type I hypersensitivity. Even though these drugs have the anti-allergic effect, they can have several side effects in prolong use. Cedrol is the main...

The objective of the present study was to determine the anticancer effects of cedrol in A549 human non-small cell lung cancer cells by examining the effects of cedrol on apoptosis induction, the phosphatidylinositol 3'-kinase (PI3K)/Akt signaling pathway, autophagy, reactive oxygen species (ROS) generation and mitochondrial transmembrane potential (MTP). The anticancer effects of cedrol were ex...

The composition of the hydrodistilled essential oils from the fruits and leaves of Thuja orientalis L. grown in Iran was analyzed by GC/MS. Nineteen and twenty-eight compounds have been identified in the volatile oils of the fruit and leaf, respectively. While the fruit oil contained alpha-pinene (52.4%), delta-3-carene (14.2%), alpha-cedrol (6.5%) and beta-phellandrene (5.1%), the leaf oil con...

BACKGROUND The extracellular matrix (ECM) produced by dermal fibroblasts supports skin structure, and degradation and/or reduced production of ECM are the main causes of wrinkle formation. OBJECTIVE The aim of this study was to identify the active ingredient that enhances ECM production in dermal fibroblasts. METHODS Polarity-based fractionation was used to isolate the active ingredient fro...

Picea abies and Larix decidua were subjected to GC/MS analyses, and antimicrobial (fungi and bacteria) assays of their stem wood and bark extracts were investigated. L. decidua bark extract exhibited the highest antifungal and antibacterial activities against the microorganisms that were screened. The microbes Penecillium ochrochloron and Aspergillus ochraceus were the most sensitive to the ext...

Plant secondary metabolites play an important role in plant-insect interactions and therefore such compounds may have insecticidal or biological activity against insects. Fumigant toxicity of essential oils of leaves and fruits from oriental arborvitae (Platycladus orientalis [L.] Franco) (Cupressaceae) was investigated against adults of cowpea weevil (Callosobruchus maculatus Fab.), rice weevi...

essential oil extracted from the leaves of lemon verbena, lippia citriodora kunth (verbenaceae) was tested for fumigant toxicity in the laboratory against two stored-product insects tribolium confusum jacquelin du val and callosobruchus maculatus (f.). the chemical composition of the isolated oil was examined by gc-ms. the major compounds were citral (11.3%), limonene (10.6%), neral (7.9%), 4-p...