نتایج جستجو برای: αα

تعداد نتایج: 184  

Journal: :The Malaysian journal of pathology 2014
Raja Zahratul Azma Othman Ainoon Alauddin Hafiza Ithnin Azlin Abudul Razak Noor Farisah Sardi Nor Hidayati Hussin Noor Hamidah

Alpha (Α) thalassaemia is the most common inherited disorder in Malaysia. The clinical severity is dependant on the number of Α genes involved. Full blood count (FBC) and haemoglobin (Hb) analysis using either gel electrophoresis, high performance liquid chromatography (HPLC) or capillary zone electrophoresis (CE) are unable to detect definitively alpha thalassaemia carriers. Definitive diagnos...

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2012
Michael A. Krause Seidina A. S. Diakite Tatiana M. Lopera-Mesa Chanaki Amaratunga Takayuki Arie Karim Traore Saibou Doumbia Drissa Konate Jeffrey R. Keefer Mahamadou Diakite Rick M. Fairhurst

BACKGROUND α-Thalassemia results from decreased production of α-globin chains that make up part of hemoglobin tetramers (Hb; α(2)β(2)) and affects up to 50% of individuals in some regions of sub-Saharan Africa. Heterozygous (-α/αα) and homozygous (-α/-α) genotypes are associated with reduced risk of severe Plasmodium falciparum malaria, but the mechanism of this protection remains obscure. We h...

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2012
Miro Janco Athanasia Kalyva Beatrice Scellini Nicoletta Piroddi Chiara Tesi Corrado Poggesi Michael A. Geeves

α-Tropomyosin (Tm) carrying hypertrophic cardiomyopathy mutation D175N or E180G was expressed in Escherichia coli. We have assembled dimers of two polypeptide chains in vitro that carry one (αα*) or two (α*α*) copies of the mutation. We found that the presence of the mutation has little effect on dimer assembly, thereby predicting that individuals heterozygous for the Tm mutations are likely to...

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2017
Anthony O. Etyang Christopher Khayeka‐Wandabwa Sailoki Kapesa Esther Muthumbi Emily Odipo Marylene Wamukoya Nicholas Ngomi Tilahun Haregu Catherine Kyobutungi Metrine Tendwa Johnstone Makale Alex Macharia J. Kennedy Cruickshank Liam Smeeth J. Anthony G. Scott Thomas N. Williams

BACKGROUND Recent studies have discovered that α-globin is expressed in blood vessel walls where it plays a role in regulating vascular tone. We tested the hypothesis that blood pressure (BP) might differ between normal individuals and those with α+thalassemia, in whom the production of α-globin is reduced. METHODS AND RESULTS The study was conducted in Nairobi, Kenya, among 938 adolescents a...

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2015
K. P. Samanta B. Samanta

In this article, we have obtained some novel results on bilateral generating functions of the polynomials, YYnn+rr αα−nnnn(xx;kk), a modified form of Konhauser biorthogonal polynomials, YYnn(xx; kk) by group-theoretic method. As special cases, we obtain the corresponding results on Laguerre polynomials, LLnn αα(xx). Some applications of our results are also discussed.

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2015
Nicole L. Umberger Tamara Caspary

Primary cilia are built and maintained by intraflagellar transport (IFT), whereby the two IFT complexes, IFTA and IFTB, carry cargo via kinesin and dynein motors for anterograde and retrograde transport, respectively. Many signaling pathways, including platelet- derived growth factor (PDGF)-AA/αα, are linked to primary cilia. Active PDGF-AA/αα signaling results in phosphorylation of Akt at two ...

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Journal: :Cukurova Medical Journal 2023

Alpha thalassemia is a genetic disease characterized by insufficient expression or definite absence of the α-globin chain. Three large deletions (thal-1; 26.5 kb MedII, 20.5 and 17.4 MedI) two small (thal-2; 4.2 3.7 kb) have been in our country. In addition, different PolyA mutations (PA1: AATAAA>AATAAG PA2: AATAAA>AATGA) on α2-globin gene (αα/αPAα), 5nt deletion (αα/α5ntα), unstable Hb v...

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Journal: :International Journal of Hematology 2021

This study investigated prenatal diagnosis of α-thalassemia and β-thalassemia in 3049 families 18 regions Hainan Province. Molecular was performed couples with thalassemia Genomic DNA extracted from peripheral blood the villus, amniotic fluid, or cord fetuses. DNA-based using polymerase chain reaction. The most commonly detected mutation for was− SEA/αα (31.53%), followed by − α4.2/αα (11.15%) ...

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Journal: :Berichte der deutschen chemischen Gesellschaft 1894

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Journal: :J. Chem. Soc., Trans. 1891

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