background: preeclampsia is a disorder unique to pregnancy and has long been recognized as an important contributor of maternal and fetal morbidity and mortality. it is suggested that cytokines such as tumor necrosis factor-alpha (tnf-α) have an important role in the pathogenesis of preeclampsia and may cause generalized endothelial dysfunction. objective: the aim of this study was comparison o...

Preeclampsia in Indonesia is the second leading cause of maternal death after bleeding with an incidence rate 3-10%. and complications among pregnant women globally. The risk preeclampsia increases as mother's weight during pregnancy. purpose this study was to determine relationship between gain at Banyumas Regency Health Center. This used a casecontrol design. results showed that most responde...

OBJECTIVE The aim of this study was to compare the levels of tumor necrosis factor-α (TNF-α) produced by peripheral blood mononuclear cells in normal pregnancies and pregnancies with complications. MATERIALS AND METHODS Maternal peripheral blood mononuclear cells from women with a recurrent spontaneous miscarriage (n = 35), premature rupture of fetal membranes (n = 30), preeclampsia (n = 27) ...

OBJECTIVE α-1 antitrypsin (AAT) is an anti-protease, anti-inflammatory and tissue-protective molecule. Normal circulating levels are <3.5 mg/dl and rise during pregnancy. Although AAT deficiency is associated with several pregnancy and placental disorders, little is known regarding AAT levels and preeclampsia. Since unopposed inflammation might contribute to preeclampsia, we studied whether pre...

Cerebrovascular complications and increased risk of encephalopathies are characteristic of preeclampsia and contribute to 40% of preeclampsia/eclampsia-related deaths. Circulating tumor necrosis factor-α (TNF-α) is elevated in preeclamptic women, and infusion of TNF-α into pregnant rats mimics characteristics of preeclampsia. While this suggests that TNF-α has a mechanistic role to promote pree...

background : preeclampsia is one of the commonest causes of prenatal and maternity related death in the world. preeclampsia is caused by multiple factors and finding any factor related to this disorder can help on time prevention of this disease, which reduces the mortality of mothers and infants. zinc deficiency is a possible risk factor for risky pregnancies and the results of studies on this...

The mechanisms of the pathogenesis of preeclampsia, a leading cause of maternal morbidity and death worldwide, are poorly understood in part due to a lack of spontaneous animal models of the disease. We hypothesized that the Dahl salt-sensitive (S) rat, a genetic model of hypertension and kidney disease, is a spontaneous model of superimposed preeclampsia. The Dahl S was compared with the Sprag...

background: we examined whether pregnant women with preeclampsia have an increased rate of pre-pregnancy polycystic ovary syndrome (pcos). this study also evaluated whether the association, if any, was a result of preeclampsia and its relationship to pcos or dependent upon concurrent obesity. materials and methods: in this study, 75 preeclampsia cases and 225 normotensive pregnant controls, mat...

Objectives: Preeclampsia is best described as a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. It is severe and clinically important manifestations of placental insufficiency. Our purpose was to study DUSP1 expression in normal human pregnancy and preeclampsia. Study design: We used ELISA, RT-PCR and Immuno-histochemistry to characteriz...

Preeclampsia is associated with increased peripheral resistance. This study was performed to determine whether an increase of venous distensibility occurs as well in preeclampsia. We obtained venous distensibility by measuring the venous pressure-volume relation in the forearm with a water-filled plethysmograph. Twenty-one women with normal pregnancy, 12 women with severe preeclampsia, and 8 wo...