aim : to evaluate the effect of active t. gondii tachyzoites and its products on the gene expression level of ifn-yr1 and ifn-yr2 in a murine model.   background : many studies have shown that the parasite toxoplasma gondii utilizes different mechanisms to inhibit the function of ifn-?, but the parasite effect on the function of ifn-yr1 and ifn-yr2 is still unclear. patients and methods : toxop...

secreted cytokines of th1 (t-helper)/th2 cells play an important role in the pathogenesis of many diseases. th1 cells secrete predominantly ifn-γ and il-2 which regulate cell-mediated immunity against intracellular pathogens and tumors. in this study, expression of ifn-γ was studied using semiquantitative rt-pcr. in brief, lymphocytes of a healthy donor were stimulated with pha (1μg/106 cell/ml...

background: ifn-g is mostly secreted by activated cd4+ , cd8+ t cells and nk cells. this cytokine has immunomodulatory, anti-cancer and anti-microbial effects and is important for prophylaxis, diagnosis and treatment of chronic infections and cancers. objective: the purpose of this study was to clone the full cdna of human ifn-g and express it in cho cell line. methods: lymphocytes from a healt...

background: considering the role of t cells in the pathogenesis of periodontitis, the purpose of this study was to compare the amount of ifnγ, il4 and il17 in advanced periodontal lesions with healthy gum areas to determine each th1, th2 and th17 cells activity in comparison with each other and finally, to compare the value and the role of humoral, cell mediate and autoimmune responses.     met...

BACKGROUND/AIMS: During an immune response, type I interferon (IFN-I) signaling induces a wide range of changes, including those which are required to overcome viral infection and suppress cytotoxic T cells avoid immunopathology. certain bacterial infections, IFN-I exerts largely detrimental effects. Although the family proteins all share one common receptor, biologic responses vary depending o...