BACKGROUND Preeclampsia is associated with increased levels of reactive oxygen species (ROS) and the antiangiogenic factor, soluble fms-like tyrosine kinase-1 (sFlt-1). Moreover, recent studies have indicated that chronic sFlt-1 excess causes hypertension in pregnant animals. The purpose of this study was to evaluate the role of ROS in mediating sFlt-1-induced hypertension in the pregnant rat. ...

The purpose of this study was to determine whether the levels of soluble fms-like tyrosine kinase-1 (sFlt-1) and placenta growth factor (PlGF) are altered during the second trimester in the plasma of women who subsequently develop preeclampsia. We performed a case-control study to compare the levels of sFlt-1 and PlGF in the preeclamptic (n=46) and normal pregnant women (n=100). The maternal pl...

In preeclampsia, the antiangiogenic factor soluble fms-like tyrosine kinase-1 (sFLT-1) is released from placenta into the maternal circulation, causing endothelial dysfunction and organ injury. A recently described splice variant, sFLT-1 e15a, is primate specific and the most abundant placentally derived sFLT-1. Therefore, it may be the major sFLT-1 isoform contributing to the pathophysiology o...

Soluble form of vascular endothelial growth factor (VEGF) receptor (sFlt-1) has been considered a key target in anti angiogenesis strategies. In this study, sFlt-1 was amplified and cloned. For recombinant production of sFlt-1 protein, Chinese hamster ovary cell line (CHO) was used. The liposome-mediated transfection with sFlt-1 gene, were detected in sFlt-1 positive cells as early as 24 hours ...

Preeclampsia is a maternal hypertensive disorder that affects up to 1 out of 12 pregnancies worldwide. It is characterized by proteinuria, endothelial dysfunction, and elevated levels of the soluble form of the vascular endothelial growth factor receptor-1 (VEGFR-1, known as sFlt-1). sFlt-1 effects are mediated in part by decreasing VEGF signaling. The direct effects of sFlt-1 on cellular metab...

Mục tiêu nghiên cứu mối liên quan giữa nồng độ PlGF, sFlt-1và tỷ số sFlt-1/PlGF với một đặc điểm lâm sàng và chỉ hóa sinh ở thai phụ có nguy cơ tiền sản giật quý 1thai kỳ tại Thái Nguyên. Nghiên được thực hiện trên 201 yếu tố 200 bình thường tuổi 1 11 tuần đến 13 6 ngày. Phương pháp mô tả cắt ngang. Kết quả cho thấy sFlt-1, ít nhiều hơn huyết áp tâm thu, trương. Nồng sFlt-1 các cũng như vài khá...

Preeclampsia is an obstetric disease that a health problem worldwide, including in Indonesia. Several studies have shown changes the maternal spiral arteries are thought to lead preeclampsia. this decade has been associated with angiogenesis regulatory proteins originating from placenta and circulating mother's blood circulation, namely soluble FMS-like tyrosine kinase 1 (sFlt-1) placental grow...

Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1...