Epidermal growth factor receptor (EGFR) has been extensively targeted in the treatment of non-small cell lung cancer, producing responses in a small number of patients. To study the role of ligand expression in mediating response to EGFR antagonism, we injected NCI-H441 [EGFR and EGF/transforming growth factor-alpha (TGF-alpha) positive] or PC14-PE6 (EGFR positive and EGF/TGF-alpha negative) hu...

of the CA is described as follows. 1. Router retrieves a new task from the task queue. If there is no task in the task queue, then ends. 2. Router generates a PE chain which is used to process a task. Set the PEs in the PE chain as busy, which means these PE can not do any other task until they are released. 3. Router sends the PE chain information and task to PE1. 4. PE1 finishes its work and ...

PE0 PE1 PE2 PE3 PE4 PE5 PE6 PE7 PE8 PE9 PE10 PE11 Student Name ID Grade John Smith 07 66 Gary Heath 05 95 Peter Smith 11 87 John Smith 04 78 Tarry Stanley 02 100 Will Hanson 01 84 Jane Antony 06 64 Mark Bloggs 13 88 Gill Pister 09 75 Min Lee 10 83 Goby Carmen 03 83 Gillian Roger 08 26 Mask RSPD Mask RSPD Mask RSPD 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0...

Astrocytes play a critical role in maintaining cerebral homeostasis and their dysregulation is thought to contribute to the pathogenesis of several diseases, including brain cancer and metastasis. Similar to the human disease, we found that lung and melanoma metastases in the mouse brain are accompanied by a reactive gliosis. To begin to study the biology of astrocytes and examine how these cel...

Carbohydrates substituted with phosphocholine (PC) and phosphoethanolamine (PE) were released from zwitterionic glycosphingolipids of the pig parasitic nematode Ascaris suum by treatment with endoglycoceramidase. Individual glycans were obtained by HPLC on porous graphitic carbon followed by high-pH anion-exchange chromatography. In addition to the known pentasaccharides Gal alpha 3GalNAc beta ...