Quantification of the peripheral nerve myelin glycoprotein P0 and antibodies to P0 is difficult due to insolubility of P0 in physiological solutions. We have overcome this problem by using the water-soluble recombinant form of the extracellular domain of P0 (P0-ED) and describe newly developed assays which allow detection and quantitation of P0 and antibodies to P0, in serum and cerebrospinal f...

and Applied Analysis 3 It is the aim of this paper to find the best possible lower power mean bound for the Neuman-Sándor mean M(a, b) and to present the sharp constants α and β such that the double inequality α < M(a, b) I (a, b) < β (17) holds for all a, b > 0 with a ̸ = b. 2. Main Results Theorem 1. p0 = (log 2)/ log [2 log(1 + √2)] = 1.224 . . . is the greatest value such that the inequality...

Mrt4 is a nucleolar component of the ribosome assembly machinery that shares notable similarity and competes for binding to the 25S rRNA GAR domain with the ribosomal protein P0. Here, we show that loss of function of either P0 or Mrt4 results in a deficit in 60S subunits, which is apparently due to impaired rRNA processing of 27S precursors. Mrt4, which shuttles between the nucleus and the cyt...

by the chain rule, so DG(0) = Id. Thus, G satisfies the assumptions of the theorem with p0, q0 resp. DF (p0) replaced by 0, 0, resp. Id. If we show that G is invertible as stated, then F(z) = p0 +G ((DF )(p0) (z − q0)) for z near q0. Indeed, substituting in z = F (p0 + y) gives F (F (p0 + y)) = p0 +G (G(y)) = p0 + y, and F (F (q0 + z)) = q0 + z is also easy to check. So from now on we assume th...

Genetic deficiency or instability of myelin protein zero (P0) results in hereditary motor sensory neuropathy. In view of recent advances in gene therapy, substitution of the molecular defect may become realistic in the near future. Here we investigate the impact of genetic deficiency of P0 on selection of the autoreactive T cell repertoire in the corresponding mouse model. We show that P0 mRNA ...

To probe into the functional properties of the major peripheral myelin cell surface glycoprotein P0, its ability to confer adhesion and neurite outgrowth-promoting properties was studied in cell culture. To this aim, P0 was expressed as integral membrane glycoprotein at the surface of CV-1 cells with the help of a recombinant vaccinia virus expression system. Furthermore, the immunoglobulin-lik...