Objective(s): To investigate the role of the microRNA-125a (miR-125a) and BAK1 in intervertebral disc degeneration (IDD). Materials and Methods: Degenerative lumbar nucleus pulposus (NP) tissues were obtained from 193 patients who underwent resection, and normal controls consisted of normal NP tissues from 32 patients with traumatic lumbar fracture in our hospital. All patients were graded acco...

Human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) are considered as a promising cell source for transplantation and have been used for organoid fabrication to recapitulate central nervous system (CNS) diseases in vitro. The establishment of three-dimensional (3D) in vitro model with hiPSC-NPCs and control of their differentiation is significantly critical for unde...

Nuclear lamin isoforms form fibrous meshworks associated with nuclear pore complexes (NPCs). Using datasets prepared from subpixel and segmentation analyses of 3D–structured illumination microscopy images WT isoform knockout mouse embryo fibroblasts, we determined high precision the spatial association NPCs specific fibers. These relationships are retained in enlarged Lmna−/− Lmnb1−/− fibroblas...

Responding to critical shortages of physicians, most sub-Saharan countries have scaled up training of nonphysician clinicians (NPCs), resulting in a gradual but decisive shift to NPCs as the cornerstone of healthcare delivery. This development should unfold in parallel with strategic rethinking about the role of physicians and with innovations in physician education and in-service training. In ...

Neural progenitor cells (NPCs) have regenerative capabilities that are activated during inflammation. We aimed at elucidating how NPCs, with special focus on the spinal cord-derived NPCs (SC-NPCs), are affected by chronic inflammation modeled by experimental autoimmune encephalomyelitis (EAE). NPCs derived from the subventricular zone (SVZ-NPCs) were also included in the study as a reference fr...

The adult Central Nervous System (CNS) harbors neural progenitor cells (NPCs) in three areas: the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone in the hippocampus and around the central canal in the spinal cord. The NPCs can be isolated and cultured in vitro. To improve recovery after a CNS trauma by using endogenous NPCs as well as by NPC transplantation, it is i...

The outbreak of nuclear power cooling water system (NPCS) disaster-causing organisms has become more frequent, causing huge economic losses. Therefore, it is necessary to understand the aggregation mechanism for risk prevention and control NPCS. Hence, this study applied Lagrangian flow network (LFN) analyze Acetes near NPCS, as such a complex can describe interconnections between massive nodes...