Several issues occur to analysis of oligonucleotide microarray data, such as MM as internal control for PM and cross-hybridization. An integrated procedure is proposed to address these problems: (1) log2 scale of PM is used for analysis to avoid bias caused by MM; (2) two-way ANOVA is employed to account for probe effect; and (3) one filter using probability of probe fold change beyond a thresh...

Through a sampling survey of the results physical fitness test students Guilin Institute Aerospace Industry in 2018, using analysis variance research method, five variable indicators surveyed were analyzed, and changes during three years university studied. The show that college, has been increasing year by year, but growth rate declining, difference is mainly due to their own high body mass in...

BACKGROUND Progenitor cells (PCs) are mobilized in response to vascular injury to effect regeneration and repair. Recruitment of PCs requires intact nitric oxide (NO) synthesis by endothelial cells, and their number and activity correlate with cardiovascular disease risk burden and future outcomes. Whereas cardiovascular vulnerability exhibits a robust circadian rhythm, the 24-hour variation of...

Increasing evidence suggests that reactive oxygen species (ROS) and oxidative stress are involved in PM-mediated lung and cardiovascular injury. The physical characteristics and the chemical composition of particulate matter (PM) play a key role in ROS generation in vitro and in vivo. The mitochondria are major subcellular targets for PM as well as a source of ROS production. ROS production is ...

Objective To evaluate the effect of aging in a hard denture reline (New Truliner) and an acrylic resin (Classic) after chemical and mechanical polishing. Methods Eighty specimens were made, divided randomly between 8 groups: G1.Acrylic Resin Classic (RAC)/Mechanical Polishing (PM); G2.RAC/PM + thermocycling (TR); G3) RAC/Chemical Polishing (PQ); G4.RAC/PQ + TR; G5.New Truliner (NT)/PM; G6.NT/PM...

BACKGROUND The aim of this study was to evaluate matrix tablets containing different ratios of Carbopol(®) 971P (CP) to low-viscosity sodium alginate (SA) and assess their suitability for pH-independent controlled drug release. METHODS Two processing methods (physical mixing, PM and spray-drying, SD) were applied before compaction and the release from corresponding matrices was compared. The ...

One of the hallmarks of statistical thinking is the importance of measuring and understanding variability. The Shewhart Control Chart, which separates special cause from common cause variation, is one of the most important tools for understanding the current state of a process. The analysis of variance (ANOVA) is another statistical tool for splitting variability into component sources. These c...

Liver injury induced by Polygonum multiflorum Thunb. (PM) have been reported since 2006, which aroused widespread concern. However, the toxicity mechanism of PM liver injury remained unclear. In this study, the mechanism of liver injury induced by different doses of PM after long-term administration was investigated in rats by metabolomics and traditional approaches. Rats were randomly divided ...