UNLABELLED We evaluated the use of radiolabeled 4-iodo-L-meta-tyrosine as an amino acid transport marker. The pharmacologic features of this compound, particularly the biodistribution and excretion, were examined by conducting in vivo and in vitro studies using 4-(125)I-iodo-L-meta-tyrosine (4-(125)I-mTyr). Results obtained for L-(14)C-Tyr and 3-(125)I-iodo-alpha-methyl-L-tyrosine ((125)I-IMT) ...

A 14-months survey was carried out to identify the species composition of Anopheles mosquitoes from Kampung Bongor, Grik, Perak. Adding to that, a preliminary one month mosquito population screening was done at Kampung Tepin, Serian, Sarawak. Consequently, the insecticide susceptibility status of a pyrethroid was tested against two selected species of Anopheles collected from these two location...

The expression of high-affinity α4β2* nicotinic acetylcholine receptors (nAChR) increases following chronic exposure to nicotinic agonists. While, nAChR antagonists can also produce upregulation, these changes are often less pronounced than achieved with agonists. It is unknown if nAChR agonists and antagonists induce receptor upregulation by the same mechanisms. In this study, primary neuronal...

INTRODUCTION High expression of the system L amino acid transporter has been observed in clinically important tissues including tumors and the blood-brain barrier. We examined amino acid transport system L selectivity of (14)C(U)-L-tyrosine ((14)C-Tyr), (125)I-4-iodo-L-meta-tyrosine (4-(125)I-mTyr), (125)I-6-iodo-L-meta-tyrosine (6-(125)I-mTyr), (125)I-3-iodo-α-methyl-L-tyrosine ((125)I-IMT) an...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 208 No. 1 125–136 www.jcb.org/cgi/doi/10.1083/jcb.201410123 JCB 125 Correspondence to Steven L. Teitelbaum: [email protected] Abbreviations used in this paper: Ab, antibody; BMM, BM macrophage; ITAM, immunoreceptor tyrosine–based activation motif; M-CSF, macrophage colonystimulating factor; RANKL, receptor activator of nuclear factor ...

PURPOSE Prostate-specific membrane antigen (PSMA) is a cell surface protein that is overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our goal in this study was to develop a series of PSMA-based imaging agents for clinical use. EXPERIMENTAL DESIGN We have synthesized and evaluated the in vivo biodistribution of two radiolabeled urea derivatives that have h...

We have studied the Kardar-Parisi-Zhang equation in the strong coupling regime in the mode-coupling approximation. We solved numerically in dimension d=1 for the correlation function at wave vector k. At large times t we found the predicted stretched exponential decay consistent with our previous saddle point analysis [Phys. Rev. E 63, 057103 (2001)], but we also observed that the decay to zero...

ABSTRACT- Chrysanthemum (Dendranthema grandiflorum) is one of the most important ornamental plants used as cut flower, flowering pot plant and groundcover worldwide. In this research, the effects of preservative solutions containing thymol (75 and 125 mg -L), menthol (75 and 125 mg L-1) and eugenol (75 and 125 mg L-1) on the quality and vase-life of chrysanthemum cut flowers at 3±1ºC and 75-80%...

Histological survey was made to determine nitrate toxicity on the Medaka fish, Oryzias latipes. In order to investigate the effects of short-term exposure to nitrate, one-month-old Medaka fish was exposed to NaNO3 at concentrations of 100 and 125 mg NO3-N l-1 for 96 hours. At the end of the exposure period, survival rate was found to be 30% and 10%, for the 100 and 125 mg NO3-N l-1 exposure con...