This study examined whether dietary supplementation can be used to protect against ischemic stroke. Two groups of adult male Sprague-Dawley rats initially received NT-020, a proprietary formulation of blueberry, green tea, Vitamin D3, and carnosine (n = 8), or vehicle (n = 7). Dosing for NT-020 and vehicle consisted of daily oral administration (using a gavage) over a 2-week period. On day 14 f...

I. Height allometries Since 1999, FIA data include height measurements. However, pre-1999 FIA data (which currently comprise most of the available plot re-measurements) do not include height data for most of the U.S. Therefore, incorporating tree height into analyses of pre-1999 FIA data requires height-dbh allometries, which we estimated using the post-1999 FIA data. Because we wished to treat...

The effects of the aquaporin-4 (AQP-4) inhibitor TGN-020 on regional cerebral blood flow (rCBF) was examined in wild-type (WT) and AQP-4 knockout (KO) mice in vivo. Although baseline absolute rCBF of WT and KO mice were equivalent (158.9 ± 17.7 and 155.5 ± 10.4 ml/100 g/min, respectively), TGN-020 produced a significant increase in rCBF compared with saline-treated WT mice (control), reaching a...

BACKGROUND Clostridium difficile infection ranges from mild to severe prolonged diarrhea with systemic symptoms. Previous studies have assessed the correlation of some disease severity parameters to C. difficile ribotypes. However, certain clinical parameters of interest have not yet been evaluated. AIM We conducted an exploratory study to evaluate the correlation of C. difficile ribotypes to...

vi CHAPTER 1: INTRODUCTION 1 1.1 Adult neurogenesis 1 1.1.1 Adult neurogenesis and cognitive function 3 1.1.2 Process of adult neurogenesis 8 1.2 Aging and neurogenesis 12 1.2.1 Aging and cognitive function 14 1.2.2 Oxidative stress and process of aging 17 1.2.3 Inflammation and aging 22 CHAPTER 2: MATERIALS AND METHODS 29 2.1 Animals 29 2.2 Surgical Procedures 29 2.2.1 Eyeblink conditioning su...

Abstract Study question Does advancing male age influence the frequency of occurrence sperm abnormalities? Summary answer Advancing was associated with increased incidence certain head and tail defects – elongated head, nuclear vacuoles, coiled tail. What is known already Evaluation reproductive potential based mainly on motility morphology. Morphological features serve as a reliable indicator ...