Many epithelia have a common planar cell polarity (PCP), as exemplified by the consistent orientation of hairs on mammalian skin and insect cuticle. One conserved system of PCP depends on Starry night (Stan, also called Flamingo), an atypical cadherin that forms homodimeric bridges between adjacent cells. Stan acts together with other transmembrane proteins, most notably Frizzled (Fz) and Van G...

Abstract In this paper, we introduce a new class of control functions, namely extended $\mathcal{FZ}$ FZ -simulation and employ it to define contractive condition. We also prove some fixed best proximity point results in the context an M -complete fuzzy metric space. The presented theorems unify, generalize, im...

BACKGROUND The frizzled (fz) gene of Drosophila encodes the founding member of the large family of receptors for the Wnt family of signaling molecules. It was originally studied in the adult epidermis, where it plays a key role in the generation of tissue polarity. Mutations in components of the fz signal transduction pathway disrupt tissue polarity; on the wing, hairs normally point distally b...

S U M M A R Y The detailed structure of fault zones (FZs) plays an important role in problems related to fault mechanics, earthquake rupture, wave propagation and seismic hazard. FZs are thought to consist of an O(10–100) m wide region of decreased seismic velocity but structural details such as their depth extent, lateral and vertical variations, etc. are elusive. The small spatial scales invo...

The sensory bristles of the fruit fly Drosophila are organized in a polarized fashion such that bristles on the thorax point posteriorly. These bristles are derived from asymmetric division of sensory organ precursors (SOPs). The Numb protein, which is localized asymmetrically in a cortical crescent in each SOP, segregates into only one of the two daughter cells during cell division, thereby co...

background and aim: auditory p300 is an event-related potential. cognitive factors like attention are involved in the generation of p300. it seems that normative variation of p300 is necessary for clinical purposes. thus, the current study was designed to establish preliminary normative variation of p300 amplitude and latency at fz and cz sites in adults. methods: this cross-sectional study was...

Members of the Frizzled (Fz) family of seven-pass transmembrane receptors are required for the transduction of both Wnt-Fz/beta-catenin and Fz/planar cell polarity (PCP) signals. Although both pathways transduce signals via interactions between Fz and the cytoplasmic protein Dishevelled (Dsh), each pathway has specific and distinct effectors. One explanation for the pathway specificity is that ...

High-dosage buprenorphine (BUP) consumed concomitantly with benzodiazepines (BZDs) including flunitrazepam (FZ) may cause life-threatening respiratory depression despite a BUP ceiling effect and BZDs' limited effects on ventilation. However, the mechanism of BUP/FZ interaction remains unknown. We hypothesized that BUP may alter the disposition of FZ active metabolites in vivo, contributing to r...