Delayed cerebellar development is a hallmark of Zellweger syndrome (ZS), a severe neonatal neurodegenerative disorder. ZS is caused by mutations in PEX genes, such as PEX13, which encodes a protein required for import of proteins into the peroxisome. The molecular basis of ZS pathogenesis is not known. We have created a conditional mouse mutant with brain-restricted deficiency of PEX13 that exh...

(a) The curves z(s) and z(s, t) were not required to be simple curves. This made the task of approximating them with continuously differentiable curves very easy. (b) The Cauchy integral theorem also holds if the function z(s) describing the curve C is merely piecewise continuously differentiable. For in this case we carry out the integration by parts in (6) over each subinterval on which zs(s)...

The Testin (TES) gene was previously identified as a putative human tumor suppressor gene at 7q31.2, a region that is frequently deleted in hematopoietic malignancies, as well as in epithelial tumors. To determine whether TES acts as a tumor suppressor in vivo, we generated a Tes knockout mouse and then used it in an established model of carcinogen-induced gastric cancer. In mice a zinc-deficie...

BACKGROUND The Democratic Republic of the Congo (DRC) began polio eradication activities in 1996. By 2001, DRC was no longer polio endemic. However, wild poliovirus (WPV) transmission was reestablished in 2006 continuing through 2011 (last WPV case onset 20 December 2011), and vaccine-derived poliovirus type 2 (VDPV2) outbreaks occurred during 2004-2012 (last VDPV2 case onset 4 April 2012). Gap...

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Cyhalothrin is a common environmental pollutant which poses increased risks to non-target organisms including human beings. This study reported for the first time a newly isolated strain, Bacillus thuringiensis ZS-19 completely degraded cyhalothrin in minimal medium within 72 h. The bacterium transformed cyhalothrin by cleavage of both the ester linkage and diaryl bond to yield six intermediate...

Zero-resource speech processing (ZS) systems aim to learn structural representations of speech without access to labeled data. A starting point for these systems is the extraction of syllable tokens utilizing the rhythmic structure of a speech signal. Several recent ZS systems have therefore focused on clustering such syllable tokens into linguistically meaningful units. These systems have so f...

The element phosphorus (P) is essential to all life (e.g. plants, animals and bacteria) and is a key ingredient in fertilizers to sustain high crop yields. However, the lifetime of exploitable reserves of natural ore deposits containing P is estimated to range from the next few decades to several hundreds of years, since P is intensively used in agriculture and other industries. The use of P yi...

The $AKARI$ space infrared telescope has performed near- to mid-infrared (MIR) observations on the North Ecliptic Pole Wide (NEPW) field (5.4 deg$^2$) for about one year. took advantage of its continuous nine photometric bands, compared with NASA's $Spitzer$ and WISE telescopes, which had only four filters a wide gap in MIR. NEPW lacked deep homogeneous optical data, limiting use nearly half IR...

Identification of the Peroxisomal Biogenesis Factor 1 Gene Point Mutation in an Iranian Family with Zellweger Syndrome (ZS)