The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several vasodilating factors, including prostacyclin, NO, and endothelium-derived hyperpolarizing factor (EDHF). We have recently identified that endothelium-derived H2O2 is an EDHF in mesenteric arteries of mice and humans and in porcine coronary microvessels. However, the mechanism for th...

The Cu,Zn superoxide dismutase (SOD) of Aspergillus fumigatus has previously been purified and shown to be immunoreactive to the sera of patients with aspergillosis; however, the purification of large quantities of the enzyme for expanded immunological analysis is both difficult and time-consuming. Accordingly, a lambdaEMBL3 A. fumigatus genomic library was screened with degenerate oligonucleot...

Amyotrophic lateral sclerosis (ALS) involves the progressive degeneration of motor neurons in the spinal cord and the motor cortex. It has been shown that 15-20% of patients with familial ALS (FALS) have defects in the Sod1 gene, which encodes Cu,Zn-superoxide dismutase (SOD). To elucidate the pathological role of mutated Cu,Zn-SOD, we examined the issue of whether mutated Cu,Zn-SOD affects the...

To define the mechanism of nitric oxide (NO) action in the glomerulus, we attempted to identify genes that are regulated by NO in rat glomerular mesangial cells. We identified a Cu/Zn superoxide dismutase (SOD) that was strongly induced in these cells by treatment with S-nitroso-glutathione as a NO-donating agent. Bacterial lipopolysaccharide (LPS) acutely decreased Cu/Zn SOD mRNA levels. The L...

Profiles of some trace elements (Fe Mn, Zn, Cu, pb and Cd) were detected in saline water and surficial sediment of Wadi El-Natrun depression lakes. The trace elements concentrations largely indicate the influence of weathering of terrigenous sources on land. The order of the studied trace elements in brine lakes of Wadi El-Natrun from high to low concentrations are Mn > Pb > Fe > Zn > Cu > Cd a...

in order to evaluate the effect of foliar application of micro nutrients on physiological growth indices and total dry matter yield of forage corn. field experiment was conducted in 2006 at bersian village isfahan. a randomized complete block design with four replications was used. plant treated with 8 foliar application treatments (fe, zn, cu, mn, fe + mn, cu + zn, fe + mn + cu + zn and contro...

It is well known that compost can be polluted with heavy metals. A self-designed soil column system was used to clarify the leaching or residue of heavy metals when compost was added to red soil. Less than 4% of Cu and more than 58.3% of Zn were transferred to groundwater. Maximum concentrations of Cu and Zn in leachate were 22 and 246 microg/L, respectively. pH in leachate decreased during 6.7...

The excitation function of the Zn(p, 2p)Cu reaction was measured radiochemically up to a proton energy of 71 MeV to obtain accurate data for production of the therapy related β−-emitting radioisotope Cu (T1/2 = 61.9 h). Investigations were also made on the (p, 2n) and (p, 3n) reactions on Zn. The experimental cross sections of the Zn(p, 2p)Cu, Zn(p, 2n)Ga and Zn(p, 3n)Ga reactions were compared...

the human erythrocyte is a rich raw material for the purification of cu-zn superoxide dismutase (sod). we applied a simple and rapid procedure for the purification of sod from human erythrocytes by ion exchange chromatography. the purified sod had a specific activity of 2285.6 u/mg protein and gave a single band on polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (sd...

This study represents the synthesis of dibenzo and dibenzodiaza crown ether precursors with various functional groups in good yield by employing four different methods using polar protic and aprotic solvents with high boiling points. Also the complexation abilities of all synthesized ligands with Cu , Zn , and Ag were studied by conductometry; thus the conductometric behavior of Cu(NO3)2, ZnCI2...