Metalloenzymes of the Lineage of Molecular Subclass B1), New Members Flavobacterium odoratum (Formerly Myroides odoratimimus and Myroides odoratus TUS-1 and MUS-1 from-Lactamases β Chromosome-Encoded

With the goal to study the mechanisms of dinuclear metalloenzymes, new synthetic and computational models for such proteins were prepared and studied. Multidentate ligands based on a central phenolate and with imidazoleand carboxylate-containing donor moieties were synthesized to simulate carboxylate-rich ligand environments. The two ligands that were found to be the most useful, were the symme...

Dioxygen activations constitute one of core issues in copper-dependent metalloenzymes. Upon O2 activation, metalloenzymes such as particulate methane monooxygenases (pMMOs), lytic polysaccharide (LPMOs) and binuclear copper enzymes PHM DβM, are able to perform various challenging C–H bond activations. Meanwhile, copper-oxygen containing complexes have been synthetized mimic the active species a...

Natural metalloenzymes are a continuing source of inspiration for the design of bio-inspired catalyst. Key to their high catalytic efficiencies and excellent (enantio)selectivities are the second coordination sphere interactions provided by the protein scaffold. The emerging concept of hybrid catalysis is an effort to impart enzyme-like characteristics to homogeneous transition-metal catalysts ...