As it was established in our previous studies, the proteins of human serum γ-globulin fraction could interact with copper or zinc ions distributed in the periglobular space, form metal complexes, and become able to perform effector functions differing due to the conformational shifts from those mediated by them in native conformation of their Fc regions. In the present work we have evaluated ab...

The activation process of secretory or membrane-bound zinc enzymes is thought to be a highly coordinated process involving zinc transport, trafficking, transfer and coordination. We have previously shown that secretory and membrane-bound zinc enzymes are activated in the early secretory pathway (ESP) via zinc-loading by the zinc transporter 5 (ZnT5)-ZnT6 hetero-complex and ZnT7 homo-complex (zi...

The reaction of copper(II) chloride and zinc(II) chloride with N-(2-methylphenyl)-3-(1'-salicylaldehydene-2'-imine-ethane)-butanamide(H2L2a) or (MPSB), N-(2-methylphenyl)-3-(1'-(3'-methoxysalicylaldehydene-2'-imine-ethane)-butanamide (H2L2b) or (MPMSB) and N-(2-methylphenyl)-3-(1'-(2'-hydroxyacetylene-2'-imine-ethane)-butanamide (H2L2c) (MPHB) leads to the formation of a series of new complexes...

A series of racemic 2-[(2′-(dimethylamino)binaphthyl-2-ylimino)methyl]-4-R2-6-R(1)-phenols (L1H–L6H) were reacted with 1 equiv. of Mg[N(SiMe3)2]2 or Zn[N(SiMe3)2]2 to provide three heteroleptic magnesium silylamido complexes [(L4–(6))MgN(SiMe3)2] (4a: R(1) = R(2) = cumyl; 5a: R(1) = CPh3, R(2) = Me; 6a: R(1) = CPh3, R(2) = (t)Bu) and one heteroleptic zinc silylamido complex [(L(4))ZnN(SiMe3)2] ...

A series of mononuclear zinc thiolate complexes have been prepared and fully characterized. The reactions of the complexes with alkyl halides, leading to zinc halides and the corresponding thioethers, have been examined by kinetic methods. In toluene, the reactions obey a second-order rate law displaying activation parameters consistent with a S(N)2 attack of the zinc-bound thiolate on the carb...

Zinc thiolate complexes containing N2S tridentate ligands were prepared to investigate their reactivity toward reactive nitrogen species, chemistry proposed to occur at the zinc tetracysteine thiolate site of nitric oxide synthase (NOS). The complexes are unreactive toward nitric oxide in the absence of dioxygen, strongly indicating that NO cannot be the species directly responsible for S-nitro...

2,2-Bipyridine chelates 2 zinc ions of horse liver alcohol dehydrogenase with a dissociation constant of 4.0 X low4 M. The complex shows an absorption maximum at 308 rnp with a difference extinction coefficient of 1 .l X lo4 M+ cm-r per zinc ion. Because bipyridine binds the enzyme less tightly than o-phenanthroline, and because the principal absorption maximum of the difference spectrum appear...

CPL active enantiopure zinc(ii) complexes based on the first tetradentate salen ligands surrounded by [4]helicene moieties and chiral 1,2-cyclohexane-diamine are reported.

The role of zinc in the catalytic action of yeast alcohol dehydrogenase has been studied through the kinetics of the inhibition of activity by chelating agents (I), particularly l,lO-phenanthroline (2-4). In aqueous solution the complexes of 1, lo-phenanthroline with Zn++ ions exhibit characteristic absorption spectra, as do the complexes of this agent with the zinc atoms of yeast alcohol dehyd...