OBJECTIVE The increase in asthma prevalence has been documented worldwide, affecting many races living in many different climates. Multiple studies have demonstrated that the most striking prevalence and morbidity of asthma in the United States has been in black children, but little research has determined the scale of the increase, or specifically when the disease became severe in this group. ...

On April 29, 2015, the neuroscience community lost an accomplished and beloved scientist when Dominique Muller died in an accident in the French Alps south of Grenoble. He passed away doing his favorite pastime: plane gliding. Dominique had a fiery curiosity that is at the heart of good science. He lived his passion for research in the laboratory, combining experimental creativity, warm mentors...

Prediction of clinical efficacy, toxicity, and drug-drug interactions may be improved by accounting for the intracellular unbound drug concentration (Cunbound) in vitro and in vivo. Furthermore, subcellular drug distribution may aid in predicting efficacy, toxicity, and risk assessment. The present study was designed to quantify the intracellular Cunbound and subcellular localization of drugs i...

Institute of Environmental Systems Barbarastraße 12, D-49076 Osnabrueck, Ge 2 38 64 3668 Department of Biology/Chemistry, Divisio Barbarastraße 13, D-49076 Osnabrueck, Ge Environmental Mineralogy, Institute for Ap Darmstadt, Schnittspahnstr. 9, D-64287 Da † Electronic supplementary informa 10.1039/c3em00214d ‡ Present address: Water, Environment an Recherches Géologiques et Minières (BRG 36009,...

The development of MT system design is described in four periods: the early experimental period (1946-54), the period of large-scale research on 'direct translation' systems (1956-66), the period after the ALPAC report in which the 'interlingual' and 'transfer' approaches were developed (1966-75), and the current period in which interactive systems and 'artificial intelligence' approaches have ...

In 1956, Goldberg (1) described the probability of developing cancer during two time periods—1940 and 1950. To compute probabilities, data on cancer morbidity and mortality from 1942-1944 and 19491951 were combined, respectively, with life-table data for the three year-periods 1939-1941 and 1949-1951. The analysis was based on the population of upstate New York (New York State exclusive of New ...

Article history: Received 2 April 2009 Received in revised form 24 September 2009 Accepted 9 November 2009 Available online 27 November 2009 The aim of the study was to investigate the relationship between the Flynn effect and the effects of age differences between siblings on the intelligence difference between them. In Norway, the secular trends in intelligence-test score means vary both in m...