BACKGROUND Hypoxia-inducible factor 1 alpha (HIF-1alpha), a component of HIF-1, is expressed in human tumors and renders cells able to survive and grow under hypoxic (low-oxygen) conditions. YC-1, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole, an agent developed for circulatory disorders that inhibits platelet aggregation and vascular contraction, inhibits HIF-1 activity in vitro. We tested wh...

Restricted feeding and high concentrate diets are potential strategies for growing dairy heifers. Ruminal manipulation with additives such as Saccharomyces cerevisiae yeast culture (YC) has been shown to alter digestibility when added to this type of diet. An experiment was conducted to investigate the ruminal fermentation and in situ digestibility of diets with 3 different levels of forage to ...

Internal and external quality characters of poultry eggs are quitely important to determine egg weight. Also, the is for both hatching production. The purpose this study was modelling weight with MARS (Multivariate Adaptive Regression Splines) method using inner outsider in Lohmann LSL Classic white hybrit flock. For purpose, hybrid flock (n=60) were used. Weekly yields evaluated from 22nd week...

Suppose F = W (k)[1/p] where W (k) is the ring of Witt vectors with coefficients in algebraically closed field k of characteristic p 6= 2. We construct integral theory of p-adic semi-stable representations of the absolute Galois group of F with Hodge-Tate weights from [0, p). This modification of Breuil’s theory results in the following application in the spirit of the Shafarevich Conjecture. I...

Differences in the adaptation processes between muscle and tendon response to mechanical loading can lead non-uniform properties within muscle–tendon unit (MTU), potentially increasing injury risk. The current study analysed of triceps surae (TS) MTU 10 young (YS; 22 ± 3 yrs) older (OS; age 65 8 yrs; i.e. master) (inter)national level sprinters 11 recreationally active adults (YC; 23 detect pos...

The antagonistic crosstalk between gibberellic acid (GA) and abscisic acid (ABA) plays a pivotal role in the modulation of seed germination. However, the molecular mechanism of such phytohormone interaction remains largely elusive. Here we show that three Arabidopsis NUCLEAR FACTOR-Y C (NF-YC) homologues NF-YC3, NF-YC4 and NF-YC9 redundantly modulate GA- and ABA-mediated seed germination. These...

This study was carried out to evaluate the potential effects of 90 days-long dietary supple- mentation probiotic and yeast culture on immunity condition lambs. Fifteen Rahmani growing male lambs (about 5 months old 23.21±2.75 kg body weight) were randomly allo- cated three equal groups consisting animals each. The in first group, served as a control (group C), fed basal diet without any supplem...

The reactions of neutral ground-state yttrium (Y) atoms with 1,3- and 1,4-cyclohexadiene (CHD) were studied using crossed molecular beams. Formation of YC(6)H(6) + H(2) and YH(2) + C(6)H(6) was observed for both isomers at collision energies (E(coll)) of 31.3 and 13.0 kcal/mol. Measured product branching ratios at E(coll) = 31.3 kcal/mol indicated that YH(2) + C(6)H(6) was the dominant channel,...

Vertebrate eyes are known to contain circadian clocks, but their regulatory mechanisms remain largely unknown. To address this, we used a cell line from human retinal pigment epithelium (hRPE-YC) with stable coexpression of reporters for molecular clock oscillations (Bmal1-luciferase) and intracellular Ca2+ concentrations (YC3.6). We observed concentration-dependent increases in cytosolic Ca2+ ...