Trametes lactinea (T. lactinea), a macrofungus belonging to the family of Polyporaceae was investigated for its ability to inhibit hyaluronidase, lipoxygenase and xanthine oxidase activities in vitro. Results showed that extracts from the supernatant and mycelia of T. lactinea significantly inhibited the activities of hyaluronidase and lipoxygenase with more than 80% inhibition. The presence of...

T HE ENZYME, XANTHINE OXIDASE, is thought to play a central role in the mobilization of storage iron from the liver.1 In the presence of xanthine oxidase, xanthine is oxidized to uric acid, the enzyme acting as electron acceptor in the oxidation reaction . ‘ Coupled to the oxidation of uric acid is the reduction of ferric ferritin to the ferrous state. The livers of immature rats contain very l...

Hemizygia bracteosa (Benth.) Briq (Lamiaceae) is used in the treatment of mental disease, memory loss, HIV, malaria and had antimicrobial and hypoglycemic properties. To the authors’ knowledge, no scientific study has been done on these properties except antimicrobial and hypoglycemic properties. The phytochemical investigation focused on the quantification of phenolic compounds, flavonoids, ta...

BACKGROUND The purpose of this study is to determine the effect of L-ascorbic acid and alpha-tocopherol as well as combination of these vitamins with or without exposure to physical exercise on intensity of lipid peroxidation, activity of xanthine oxidase, activity of total antioxidative system, concentration of glutathione, and activity of catalase in the serum of guinea pigs. MATERIALS AND ...

The present investigations were undertaken to identify photochemical present in the ethanolic leaf extract of Monochoria vaginalis by GC MS/MS, evaluation of the in vitro antioxidant and cardioprotective activity against DOX-induced cardiotoxicity in rats. The invitro antioxidant potential like DPPH radical scavenging activity, Reducing Power, Superoxide anion Scavenging activity and Nitric oxi...

Ergothioneine is a thiourea derivative of histidine found in food, especially mushrooms. Experiments in cell-free systems and chemical assays identified this compound as a powerful antioxidant. Experiments were designed to test the ability of endothelial cells to take up ergothioneine and hence benefit from protection against oxidative stress. Reverse-transcription polymerase chain reaction and...

In this issue of Circulation,' Hori and colleagues report the results of using three antioxidant agents in an attempt to reduce ischemic injury in a coronary microembolization model. Repeated injections of 15-,um microspheres resulted in progressive microvascular obstruction, decreased function , and edema until the extent of embolization decreased flow to nearly zero (less than 0.08 ml/min/ g)...

BACKGROUND α-glucosidase is a therapeutic target for diabetes mellitus (DM) and α-glucosidase inhibitors play a vital role in the treatments for the disease. Furthermore, xanthine oxidase (XO) is a key enzyme that catalyzes hypoxanthine and xanthine to uric acid which at high levels can lead to hyperuricemia which is an important cause of gout. Pancreatic lipase (PL) secreted into the duodenum ...

Xanthine oxidase is a member of molybdoenzyme family and has catalytic role in purine degradation, metabolizing hypoxanthine and xanthine to uric acid with the generation of superoxides. In the present study, microtitre plate based colorimetric assay was used to screen the xanthine oxidase producing microorganisms from the soil treated with hypoxanthine with different concentrations (2mM, 4mM, ...