Writer's cramp is a task-specific focal hand dystonia characterized by involuntary excessive muscle contractions during writing. Although abnormal striatal dopamine receptor binding has been implicated in the pathophysiology of writer's cramp and other primary dystonias, endogenous dopamine release during task performance has not been previously investigated in writer's cramp. Using positron em...

Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP18, CAP18(31), CAP18(28), CAP18(22), and CAP18(21a) were the most active, with MICs as low as 0.6 microg/ml. Other cathelicidins were less active. ...

The schema which decorated the cover of Alfred H. Barr's catalogue for the exhibition Cubism and Abstract Art at the Museum of Modern Art, New York, in 1936 is paradigmatic of the way modern art has been mapped by modernist art history [2]. All those canonized as the initiators of modern art are men. Is this because there were no women involved in early modern movements? No.' Is it because thos...

Sir, There has been a growing interest in the role of the cerebellum in primary dystonia. Although this role is not yet fully understood (Sadnicka et al., 2012), an elegant paper by Hubsch et al. (2013) in Brain showed that in writer’s cramp, a form of task-specific primary hand dystonia, the cerebellum has lost its ability to modulate sensorimotor plasticity of the motor cortex. As part of the...

! Gilbert Baker designed the rainbow flag for the 1978 San Francisco's Gay Freedom Celebration. In the original eight-color version, pink stood for sexuality, red for life, orange for healing, yellow for the sun, green for nature, turquoise for art, indigo for harmony and violet for the soul.! First unveiled on 12/5/98 the bisexual pride flag was designed by Michael Page. This rectangular flag ...