BACKGROUND Infected foot wounds in patients with diabetes are the most common reason for diabetes-related hospital admission in the United States. Nonhealing foot wounds are the major precipitant of lower-extremity amputation in the diabetic population. HYPOTHESIS The null hypothesis was that there would be no difference in proportion of healing with or without use of a foot-level mechanical ...

Healing of skin wound is a multi-factorial and complex process. Proper treatment of diabetic wounds is still a major clinical challenge. Although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. The aim of this study was to evaluate healing of ovine excisional diabetic wound model. Eight 4-month-old Iranian Makoui wethers were equa...

healing of skin wound is a multi-factorial and complex process. proper treatment of diabetic wounds is still a major clinical challenge. although diabetes mellitus can occur in ruminants, healing of wounds in diabetic ruminants has not yet been investigated. the aim of this study was to evaluate healing of ovine excisional diabetic wound model. eight 4-month-old iranian makoui wethers were equa...

The purpose of this study was to evaluate the efficacy of negative pressure wound therapy (NPWT) compared with standard of care on wound healing in high-risk patients with multiple significant comorbidities and chronic lower extremity ulcers (LEUs) across the continuum of care settings. A retrospective cohort study of 'real-world' high-risk patients was conducted using Boston University Medical...

Healing of chronic wounds such as diabetic foot ulcers is a significant clinical problem. Methods of accelerating healing in these difficult lower extremity sites include use of growth factor-loaded gels, hyperbaric oxygen, grafts, and artificial skin replacements. Nitric oxide (NO) has been proposed as a possible active agent for enhancing wound healing. This study examines the in vitro and in...

Background: Wound care has often been perceived to be the domain of the nurse, yet other professions are taking a lead in this specialist area of clinical practice. Podiatrists assess, manage and evaluate the care of lower limb conditions including lower extremity wounds. It is essential that nurses and podiatrists develop partnerships and close working relationships to ensure that patients rec...

Background: Foot ulceration (DFU) is a serious complication of diabetes and new techniques that can predict wound healing may prove very helpful. We tested the ability of Medical Hyperspectral Technology (HT), a novel diagnostic scanning technique which can quantify tissue oxyand deoxyhemoglobin, to predict DFU healing. Methods: Ten T1DM patients with 21 foot ulcer sites, 13 T1DM without ulcers...

A prospective, randomised, controlled, parallel group, multi-centre clinical trial was conducted at three sites to compare the healing effectiveness of treatment of chronic lower extremity diabetic ulcers with either weekly applications of Apligraf(®) (Organogenesis, Inc., Canton, MA), EpiFix(®) (MiMedx Group, Inc., Marietta, GA), or standard wound care with collagen-alginate dressing. The prim...