Purpose of review Wolfram syndrome 1 (WS1) is an autosomal recessive disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness (DI DM OA D syndrome) associated with other variable clinical manifestations. The causative gene for WS1 (WFS1) encoding wolframin maps to chromosome 4p16.1. Wolframin has an important function in maintaining the homeostasis of the end...

A decision procedure (PrSAT) for classical (Kolmogorov) probability calculus is presented. This decision procedure is based on an existing decision procedure for the theory of real closed fields, which has recently been implemented in Mathematica. A Mathematica implementation of PrSAT is also described, along with several applications to various non-trivial problems in the probability calculus.

Finding optimal policies to minimize the mortality and morbidity of epidemic outbreaks is a top public health priority. The previous influenza pandemic and other emerging / reemerging diseases demonstrate the importance of mathematical modeling, and calls for a synergistic cooperation of epidemiologists, mathematical modelers and public health experts. The purpose of this paper is to provide an...

An overview of the solution methods for ordinary differential equations in the Mathematica function DSolve is presented. Key WordsDifferential Equation, Mathematica, Computer Algebra

We present an integration of Mathematica into Prolog using MathLink. We illustrate the interplay between the di erent components by evaluating a simple example. The motivation based on algebraic modeling as well as an application from combinatorial group theory are brie y sketched.

The work of John von Neumann in the 1940’s on self-reproducing machines as models for biological systems and self-organized complexity provides the computational legacy for CAS. Following this, the major hypothesis emanating from Wolfram (1984), Langton (1992, 1994), Kaufmann (1993) and Casti (1994) is that the sine qua non of complex adaptive systems is their capacity to produce novelty or ‘su...

Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutat...

16Comments and Opinions Body Weight After Stroke Lessons From the Obesity Paradox Nadja Scherbakov, MD; Ulrich Dirnagl, MD; Wolfram Doehner, MD, PhD (Stroke. 2011;42:3646-3650.)