In this study, we focused on the pharmacological characterization of cannabinoid receptor coupling to G protein-gated inwardly rectifying potassium (GIRK) channels. Cannabinoids were tested on Xenopus laevis oocytes coexpressing the CB(1) receptor and GIRK1 and GIRK4 channels (CB(1)/GIRK1/4) or the CB(2) receptor and GIRK1/4 channels (CB(2)/GIRK1/4). WIN 55,212-2 enhanced currents carried by GI...

In January of that year George D Lundberg, Editor of the Journal of the American Medical Association [JAMA], was sacked by the American Medical Association (Anderson 1999). Some five months later, Jerome P Kassirer, Editor of the New England Journal of Medicine, left the Journal when his contract with the Massachusetts Medical Society, the journal’s owners, was not renewed (Smith 1999). At the ...

The rainfall and runoff relationship becomes an intriguing issue as urbanization continues to evolve worldwide. In this paper, we developed a simulation model based on the soil conservation service curve number (SCS-CN) method to analyze the rainfall-runoff relationship in Guangzhou, a rapid growing metropolitan area in southern China. The SCS-CN method was initially developed by the Natural Re...

Did Southern whites leave the Democratic Party over Civil Rights or because economic development and other secular changes in the region made the party’s platform increasingly unattractive to them? Answering this central question in American political economy has been hampered by lack of micro-data on racial attitudes from both before and after the Civil Rights era. Our contribution is to uncov...