Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are two distinct neurogenetic disorders in which imprinted genes on the proximal long arm of chromosome 15 are affected. Although the SNORD116 gene cluster has become a prime candidate for PWS, it cannot be excluded that other paternally expressed genes in the chromosomal region 15q11q13 contribute to the full phenotype. AS is caused by a d...

Abstract Introduction Prader–Willi syndrome (PWS) is a rare, genetic, neurodevelopmental associated with hyperphagia and early onset obesity, growth sex hormone insufficiencies, mild-to-moderate intellectual disability, behavioral challenges such as compulsivity, anxiety, skin picking, social skills deficits temper outbursts. Given high rates of psychiatric comorbidity potential risk factors fo...