Introduction Imagine, for a second, a doorman that behaves as automatic doors do. He does not acknowledge you when you pass by, or approach. He gives no hint which door can or will open—until you wander within 10 feet of the door, whereupon he flings the door wide open. If you arrived after hours, you might stand in front of the doors for awhile before you understood that the doors are locked, ...

Driving under the influence of substances (DUI) other than alcohol has been the subject of increasing interest over the past few decades (Schulze et al., 2012). As with alcohol, research has shown that drug intake increases the risk of road traffic accidents (Elvik, 2013; Schulze et al., 2012; Verstraete & Legrand, 2014). Intervention in this area is a priority. A key factor for deterring DUI i...

In this article I examine the constraints that skeptical hypotheses must satisfy in order to be used to raise significant skeptical challenges. I argue that skeptical hypotheses do not have to be logically, metaphysically or epistemically possible. They only need to depict scenarios that are subjectively indistinguishable from the actual world and must provide some indication of how subjects ca...

Multiple sclerosis (MS) is an autoimmune demyelinating disorder that disproportionately affects middle-aged women, and capable of resulting in severe disability. However, the use disease-modifying therapies has profoundly contributed to improvement morbidity disorder. Diroximel fumarate (DRF) a second-generation drug seen success treatment relapsing-remitting MS (RRMS). While its relatively mil...

Invariant assertions play an important role in the analysis and documentation of while loops of imperative programs. Invariant functions and invariant relations are alternative analysis tools that are distinct from invariant assertions but are related to them. In this paper we discuss these three concepts and analyze their relationships. The study of invariant functions and invariant relations ...

While cannabis is the most frequently found illegal drug in drivers killed or injured in motor vehicle collisions, little is know about driving under the influence of cannabis (DUIC) in the general population. We report information on the incidence of DUIC in a representative sample of the Ontario adult population. Among all drivers, 1.9% reported DUIC in the previous 12 months. Several factors...

AIM An unprecedented decline in alcohol consumption and road mortality has been observed recently in France, but it is still unclear whether or not these changes affected driving while alcohol-intoxicated (DWI). The objective of the study was to estimate prospectively trends of excessive speed on the roads, alcohol consumption and DWI between 2001 and 2007 in a large cohort of experienced drive...