We report the case of an 18-month-old child with infantile spasms and a hypsarrhythmic electroencephalogram (EEG) pattern associated with a porencephalic cyst. Surgical removal of the cyst and its surrounding tissue was performed following failure of medical therapy. Postoperatively, the patient has been free of infantile spasms for 12 months and the EEG has normalized. He has been maintained o...

Nineteen girls with characteristic features of Rett's syndrome, including normal initial development, regression at about 12 months of age, repetitive hand movements, and severe mental handicap were studied. This represents an estimated incidence of one in 30 000 live births (one in 15 000 girls) in the west of Scotland. Although the children were often initially considered to be autistic, they...

Nous rapportons une observation d'un nourrisson de 7 mois présentant des spasmes infantiles et une microcéphalie. Elle était née à terme, en position de siège et avait présenté une asphyxie intrapartum (dépression néonatale) ayant conduit à une encéphalopathie néonatale modérée. Le diagnostic de Syndrome de West était confirmé à l'électroencéphalographie qui avait montré un tracé hypsarythmique...

PURPOSE Familial periventricular heterotopia (PH) represents a disorder of neuronal migration resulting in multiple gray-matter nodules along the lateral ventricular walls. Prior studies have shown that mutations in the filamin A (FLNA) gene can cause PH through an X-linked dominant pattern. Heterozygotic female patients usually remain asymptomatic until the second or third decade of life, when...

Objective: This study was done to explore the relationship between components of metabolic syndrome and smoking. Materials and Methods: In this analytical cross-sectional study in Ahvaz, south west of Iran, the gathering data sheet was completed. Body mass index, abdominal and waist circumference, Fasting Blood sugar, Triglyceride, total cholesterol, LDL and HDL levels, systolic and diastolic ...

The etiopathogenesis and radiographic features of navicular syndrome remain controversial. However, as our knowledge of pathophysiology increases, better decisions regarding radiographic interpretation are made. Employment of magnetic resonance imaging and computed tomography will lead to earlier, more accurate diagnosis of navicular syndrome. Authors’ address: School of Veterinary Medicine, 12...

A controlled, randomized, double-blind trial of malaria prophylaxis in tropical splenomegaly syndrome showed a significant reduction in spleen size and an improvement of anaemia and symptoms in patients treated with antimalarials compared with control subjects receiving placebo. This study confirms the observations from West Africa and provides further indirect evidence for a malarial aetiology...

West syndrome is a triad of infantile spasms with hypsarrhythmia and developmental regression. It results in poor neurodevelopmental outcome due to delayed diagnosis treatment which further compounded by delay referral multidisciplinary interventions. Our case was male child west who came us at 3 years age concerns global features autism spectrum disorder. Based on thorough evaluation he starte...

A young West Indian with sickle-cell disease and the nephrotic syndrome in the last trimester of pregnancy was treated after admission to hospital with folic acid and blood transfusion. Labour was induced by intravenous prostaglandin E2 but the fetus died. The nephrotic syndrome resolved but the proteinuria, the cause of which it is suggested is a true sickle-cell nephropathy, persisted.