Introduction: Alexander disease is a heterogenous group of diseases with various manifestations based on age of disease onset. This rare leukodystrophy syndrome with mutations in GFAP Gene could present with developmental delay and seizure in infantile form to ataxia and bulbar palsy in adulthood. However psychiatric symptoms are not well-defined and usually evaluate after disease diagnosis not...

In recent decades agriculture has undergone rapid technological and structural changes. This development has raised concerns about the sustainability of modern agriculture and motivated an interest in alternative and, perhaps, more sustainable agricultural systems. Agriculture involves both ecological and social systems, and research in agricultural systems therefore faces the dual challenge of...

Although it's difficult to achieve, physicians can be engaged and supportive of quality improvement efforts, if the activity is presented and managed effectively.

We begin by giving away our punch line: A lack of physiological insight is the primary impediment to the successful prediction of the ecological effects of climatic change. To be sure, there are uncertainties in our predictions of future climate, especially at the local scale, and the complexities of ecological interactions stretch our ability to model complex systems. But it is physiology— our...

We begin by giving away our punch line: A lack of physiological insight is the primary impediment to the successful prediction of the ecological effects of climatic change. To be sure, there are uncertainties in our predictions of future climate, especially at the local scale, and the complexities of ecological interactions stretch our ability to model complex systems. But it is physiology— our...

Despite early warnings of lead toxicity, until recently this metal was added to a variety of consumer and industrial products. Today, thousands of children in the United States, and probably tens of thousands more worldwide, are suffering the consequences of exposure to lead. The lead story looms as major public policy failure that will eventually cost billions of dollars to remedy. Little is k...