The primary membrane of vaccinia virus, as well as those of other poxviruses, forms within a discrete cytoplasmic factory region. We recently determined the existence of an operative pathway from the endoplasmic reticulum within the virus factory to nascent viral membranes and demonstrated that a viral protein could be diverted from this pathway to Golgi membranes by the addition of COPII-bindi...

• 類推研究における 2種類の関係性構造の抽出 (Reeves & Weisberg, 1994) − Automatic schema abstraction > 複数事例の記憶・再生の経験によって抽出 > 新規問題に対しては,特徴の適合度に基づき貯蔵された事例が活性化し,その表象によって抽 象的スキーマが形成される (Goldinger, 1998; Hintzman, 1986) − Comparison-based abstraction (Strategic schema abstraction) > 問題同士を顕在的に比較するときに行われる > 2つの問題に共通する関係構造に着目し,その関係性構造が元の問題とは別に保存される (Kotovsky & Gentner, 1996; Namy & Gentner, 2002; Ross, 1984, 1989; Ross & ...

Binary radio pulsars are superb tools for mapping binary orbits, because of the precision of the pulse timing method (e.g Taylor & Weisberg 1989). To date, all orbital parameters for binary pulsars have been derived from observations of the pulsar alone. We present the rst observations of the radial velocity variations due to the binary motion of a companion to a radio pulsar. Our results demon...

Journal of Marketing Research Vol. XLI (February 2004), 116–131 *Olivier Toubia is a graduate student, Marketing Group (e-mail: [email protected]), John R. Hauser is Kirin Professor of Marketing (e-mail: [email protected]), and Duncan I. Simester is a professor (e-mail: [email protected]), Sloan School of Management, Massachusetts Institute of Technology (MIT). The authors gratefully acknowledge the ...

Longitudinal studies are increasingly common in psychological and social sciences research. In these studies, subjects are measured repeatedly across time and interest often focuses on characterizing their growth or development across time. Mixed-effects regression models (MRMs) have become the method of choice for modeling of longitudinal data; variants of MRMs have been developed under a vari...

Finding that an association is statistically insignificant in a clinical trial has two distinct explanations. (1) The association may be real, but the sample size is too small to distinguish the results from those due to chance. (2) The association is spurious – a coincidence due to chance. Based on Weisberg (2011), this paper argues that there is a third explanation: the association may be rea...

While the covalent bond plays a central role in chemical predictions, interventions, and explanations, it is a difficult concept to define precisely. This paper investigates the structural conception of the covalent bond, which says that bonding is a directional, sub-molecular region of electron density located between individual atomic centers that is responsible for holding the atoms together...

Lambda Xis, which is required for site-specific excision of phage lambda from the bacterial chromosome, has a much shorter functional half-life than Int, which is required for both integration and excision (R. A. Weisberg and M. E. Gottesman, p. 489-500, in A. D. Hershey, ed., The Bacteriophage Lambda, 1971). We found that Xis is degraded in vivo by two ATP-dependent proteases, Lon and FtsH (Hf...

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