This study employed an in situ hybridization technique to compare the cellular expression of oestrogen receptor (ER) subtypes, ER and , in the female reproductive organ of the rat during prenatal and postnatal periods. Diffuse signals of ER and mRNAs were co-expressed in the foetal ovary; they were weak and inconsistent before onset of gonadal differentiation, but increased in intensity with ag...

There exist three equivalent de®nitions of perfect Nash equilibria which di ̈er in the way ``best responses against small perturbations'' are de®ned. It is shown that applying the spirit of these de®nitions to rationalizability leads to three di ̈erent re®nements of rationalizable strategies which are termed perfect (Bernheim, 1984), weakly perfect and trembling-hand perfect rationalizability, re...

OBJECTIVE Paliperidone extended-release tablet (paliperidone ER) is a new oral psychotropic agent developed for schizophrenia treatment. There have been some studies about paliperidone's good efficacy and tolerability. Clinicians appear to change the antipsychotic medication to paliperidone ER. However, it is not known what patients are favorable responsive to paliperidone ER. The aim of this s...

Mammalian transcription factor ATF6 is constitutively synthesized as a type II transmembrane protein embedded in the endoplasmic reticulum (ER). Upon ER stress ATF6 is transported to the Golgi apparatus where it is cleaved to release its cytoplasmic domain. This is then translocated into the nucleus where it activates transcription of ER-localized molecular chaperones and folding enzymes to mai...

BACKGROUND In human breast cancer, a growth status switched from estrogen-dependent to growth factor-dependent is a critical step during development of acquired tamoxifen resistance. However, the molecular mechanisms underlying this switch remain poorly understood. The Wilms' tumor suppressor gene, WT1, encodes a zinc-finger protein WT1 that functions as a transcription regulator. High levels o...

Let Ω ⊂ Ω̃ be open sets in R, I ⊂ R be an open neighborhood of the origin and let η be a compactly supported smooth function on Ω× I; we assume that η(·, 0) does not vanish identically. For each x ∈ Ω let t 7→ Γ(x, t) ⊂ Ω̃ be a regular parametrization of a submanifold Mx ⊂ Ω̃ with codimension l. We assume that Γ(x, t) ⊂ Ω if (x, t) ∈ supp η, and that Γ satisfies Γ(x, 0) = x and depends smoothly on...

Huber, Krokhin, and Powell (2013) introduced a concept of skew bisubmodularity, as a generalization of bisubmodularity, in their complexity dichotomy theorem for valued constraint satisfaction problems over the three-value domain, and Huber and Krokhin (2014) showed the oracle tractability of minimization of skew-bisubmodular functions. Fujishige, Tanigawa, and Yoshida (2014) also showed a min-...