Around the globe, hypertension is the major cause of fatal and nonfatal cardiac, neurological, vascular and renal disease. Hypertension is treatable; the treatment works. How are these facts to be applied across the spectrum of economies and healthcare delivery systems from highly developed nations to lowand middle-income countries? Even within the developed nations, there are subpopulations wi...

Two water channel homologs were cloned recently from rat kidney, mercurial-insensitive water channel (MIWC) and glycerol intrinsic protein (GLIP). Polyclonal antibodies were raised against synthetic C-terminal peptides and purified by affinity chromatography. MIWC and GLIP antibodies recognized proteins in rat kidney with an apparent molecular mass of 30 and 27 kDa, respectively, and did not cr...

From 1 January 1995 until 1 January 1996, we studied the molecular epidemiology of blood isolates of coagulase-negative staphylococci (CoNS) in the Neonatal Intensive Care Units (NICUs) of the Sophia Children's Hospital (SCH; Rotterdam, The Netherlands) and the Wilhelmina Children's Hospital (WCH; Utrecht, The Netherlands). The main goal of the present study was to detect putatively endemic clo...

T he Centers for Medicare and Medicaid Services (CMS) in the United States have recently approved ambulatory blood pressure measurement (ABPM) for reimbursement, but only for “patients with suspected WCH (white coat hypertension)” in whom the CMS believes the information deriving from the technique “is necessary in order to determine the appropriate management of the patient.” This decision, wh...

Background: DNA molecule of the eukaryotic cells is found in the form of a nucleoprotein complex named chromatin. Two epigenetic modifications are critical for transcriptional control of genes, including acetylation and DNA methylation. Hypermethylation of tumor suppressor genes is catalyzed by various DNA methyltransferase enzymes (DNMTs), including DNMT1, DNMT2, and DNMT3. The most well chara...

BACKGROUND High blood pressure (BP) poses a major risk for cognitive decline. Aim of the study was to highlight the relationship between cognitive assessment scores and an effective therapeutic BP control. METHODS By medical visit and ambulatory BP monitoring (ABPM), we studied 302 treated hypertensives, subdivided according to office/daytime BP values into 120 with good (GC) and 98 poor (PC)...

Objectives: To find out whether or not there are some gender differences according to prevalence and underlying risk factors of coronary heart disease (CHD). Methodology: The study was performed in the Internal Medicine Polyclinic on consecutive patients coming with any complaint at and above the age of 15 years between August 2005 and March 2007. Patients under 15 years of age are examined in ...

Two recently cloned water channels, CHIP28 and WCH-CD, are homologous to MIP26, an integral membrane channel-forming protein found in lens fiber plasma membranes. CHIP28 is found in basolateral and apical plasma membranes of kidney proximal tubules and thin descending limbs of Henle, whereas WCH-CD is apically located in collecting duct principal cells. So far, the putative water channel that m...

In this work, we demonstrate atomic-layer-deposited (ALD) single-channel indium oxide (In2O3) gate-all-around (GAA) nanoribbon FETs in a back-end-of-line (BEOL) compatible process. A maximum on-state current (ION) of 19.3 mA/{\mu}m (near 20 mA/{\mu}m) is achieved an In2O3 GAA FET with channel thickness (TIO) 3.1 nm, length (Lch) 40 width (Wch) 30 nm and dielectric HfO2 5 nm. The record high dra...

late H. L. Barnard, m.s., f.r.c.s., Surgeon to the London Hospital. Edited by James Siierren, kr.c.s., Surgeon to the London Hospital, etc. ith numerous Illustrations. Publishers : Edward Arnold, 1910. PriceL5s.net. Ihis is a posthumous publication, and is a most suitable memorial to Barnard, whose untimely death was an undoubted loss to om gei} . I he greater part of the book deals with the su...