Evidence Three large international RCTs in females aged 15 to 26 used modified intention-to-treat analysis (including patients with positive test results for HPV at baseline) for all HPV lesions.1-4 • Quadrivalent vaccine (HPV 6, 11, 16, and 18): -FUTURE 1 trial1 following 5455 women for 4 years found decreased external genital lesions (3.8% vs 5.7% [placebo]; number needed to vaccinate [NNV] =...