The ability of cancer cells to evade apoptosis may permit survival of a recombinant vaccinia lacking antiapoptotic genes in cancer cells compared with normal cells. We have explored the deletion of two vaccinia virus host range/antiapoptosis genes, SPI-1 and SPI-2, for their effects on the viral replication and their ability to induce cell death in infected normal and transformed cells in vitro...

BACKGROUND Health-related quality of life (HRQL) outcome measures are complex and for further application in clinical practice and health service research the meaning of their scorings should be studied in depth. The aim of this study was to increase the interpretability of the Spanish VSP-A and KINDL-R scores. METHODS A representative sample of adolescents aged 12 to 18 years old was selecte...

New anti-cancer drugs that inhibit the vascular endothelial growth factor (VEGF) signaling pathway are highly effective in the treatment of solid tumors, however concerns remain regarding their cardiovascular safety. The most common side effect of VEGF signaling pathway (VSP) inhibition is the development of systemic hypertension. We review the incidence, possible mechanisms, significance and m...

Citation: Kohout SC and Villalba-Galea CA (2015) Editorial: Phosphoinositides and their phosphatases: Linking electrical and chemical signals in biological processes. The voltage-sensing phosphatase (VSP) has changed the way we think about both cellular electrical activity and PIPs (phosphatidylinositol phosphates). Originally discovered in 1999 (Chen et al., 1999), these proteins were not reco...

The sensing of transmembrane electrical potential has long been thought to be unique to voltage-gated ion channels. Recently, however, transmembrane voltage has been shown to regulate the enzymatic activity of a protein, called voltage-sensing phosphatase (VSP), that is conserved across diverse phyla (Murata et al., 2005; Murata and Okamura, 2007; Hossain et al., 2008). In VSP, the voltage sens...

Ci-VSP contains a voltage-sensing domain (VSD) homologous to that of voltage-gated potassium channels. Using charge displacement ('gating' current) measurements we show that voltage-sensing movements of this VSD can occur within 1 ms in mammalian membranes. Our analysis lead to development of a genetically encodable fluorescent protein voltage sensor (VSFP) in which the fast, voltage-dependent ...

The Vertex Separator Problem (VSP) on a graph is the problem of finding the smallest collection of vertices whose removal separates the graph into two disjoint subsets of roughly equal size. Recently, Hager and Hungerford [1] developed a continuous bilinear programming formulation of the VSP. In this paper, we reinforce the bilinear programming approach with a multilevel scheme for learning the...

Abstract The processing efficiency of the widely used time-space (t-x) domain vertical seismic profiling (VSP) wavefield separation methods (such as median and singular value decomposition filtering) via one-dimensional discrete Fourier transform (DFT) depends on method (or algorithm with parameter) total number samples in input VSP data. Once is determined, its set cannot be optimized. Althoug...

Due to a variety of motions across different frames, it is highly challenging learn an effective spatiotemporal representation for accurate video saliency prediction (VSP). To address this issue, we develop feature alignment network tailored VSP, mainly including two key sub-networks: multi-scale deformable convolutional (MDAN) and bidirectional Long Short-Term Memory (Bi-ConvLSTM) network. The...

I realize and analyze a model-based joint tomography scheme in this paper. Surface reflection seismic data and VSP traveltimes are used simultaneously to invert the velocity by using an integrated inversion scheme. Since more data are used, the integrated tomography can obtain more accurate inversion results with lower uncertainty. Using identity operator as integration operator, I apply this m...