Organic isothioc.vanates block the production of tumors induced in rodents by diverse carcinogens (polve-velie aromatic hydrocarbons, ¡i/o dyes, ethionine, jV-2-fluorenylacetamide, and nitrosamines). Protection is afforded by a-naphthyl-, ß-naphthyl-, phenyl-, benzyl-, phenethyl-, and other arylalkyl isothioc.vanates against tumor development in liver, lung, mammary gland, forestomach, and es...

The choroid plexuses (CPs) form the blood-cerebrospinal fluid (CSF) barrier (BCSFB) and play an important role in maintaining brain normal function and the brain response to injury. Many neurological disorders are associated with oxidative stress that can impact CP function. This study examined the effects of isothiocyanates, an abundant component in cruciferous vegetables, on H(2)O(2)-induced ...

Cruciferous vegetables, such as Brassica, which contain substantial quantities of glucosinolates, have been suggested to possess anticarcinogenic activity. Cutting and chewing of cruciferous vegetables releases the thioglucosidase enzyme myrosinase, which degrades glucosinolates to isothiocyanates and other minor metabolites. Cooking of cruciferous vegetables inactivates the myrosinase enzyme, ...

Skin allergy is a chronic condition that affects about 20% of the population of the western world. This disease is caused by small reactive compounds, haptens, able to penetrate into the epidermis and modify endogenous proteins, thereby triggering an immunogenic reaction. Phenyl isothiocyanate (PITC) and ethyl isothiocyanate (EITC) have been suggested to be responsible for allergic skin reactio...