Transdermal delivery of ondansetron hydrochloride is one of the promising ways to maximize the therapy in contrast to oral delivery. Current investigation efforts are focused in formulating the ondansetron hydrochloride matrix-type transdermal film by incorporating hydrophilic and hydrophobic polymers. In this study, ondansetron hydrochloride transdermal films were prepared using solvent evapor...

The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig skin...

Purpose: The aim of this study was to evaluate and compare the in vitro and in vivo topical potential of solid lipid nanoparticles (SLNs) gel for capsaicin. Methods: SLNs were prepared by high shear homogenization and ultrasonication using capsaicin. Then SLNs gel was formulated by hydration method using carbopol 940. Results: The mean particle size, width of distribution, zeta potential and en...

An objective of periodontal treatment is to suppress or eliminate sub gingival periodontal pathogens. Local delivery devices for periodontitis are designed to deliver the drug locally into periodontal pocket. Satranidazole is a 5-nitroimidazole derivative active against gram negative anaerobic periodontal infections. For site specific one time continuous delivery of Satranidazole, an antimicrob...

The aim of this study is to develop a locally acting nasal delivery system of triamcinolone acetonide (TA) for the maintenance therapy of allergic rhinitis. The effect of encapsulating TA in different nanocarriers on its mucosal permeation and retention as well as in vivo nasal deposition has been studied. A comparative study was established between polymeric oil core nanocapsules (NCs), lipid ...

Diclofenac sodium loaded solid lipid nanoparticles (SLNs) were formulated using guggul lipid as major lipid component and analyzed for physical parameters, permeation profile, and anti-inflammatory activity. The SLNs were prepared using melt-emulsion sonication/low temperature-solidification method and characterized for physical parameters, in vitro drug release, and accelerated stability studi...

BACKGROUND AND AIMS The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation into the oesophageal mucosa, we measured interstitial pH (pH(int)) of the oeso...

the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...

Background and aims: The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation into the oesophageal mucosa, we measured interstitial pH (pHint) of the oesop...

11 Cutaneous leishmaniasis (CL) is caused by several species of the protozoan parasite Leishmania and 12 affects approximately 10 million people worldwide. Currently available drugs are not ideal due to high 13 cost, toxicity, parenteral administration and suboptimal efficacy. Miltefosine is the only oral 14 treatment (Impavido®) available to treat CL, given over a period of 28 days with common...