BACKGROUND A new technique for visualisation of the vitreous base is described. It uses a standard lightpipe for scleral indentation and transillumination. Visualisation of the vitreous using low light levels can be achieved by enhancing the Tyndall effect. DISCUSSION Perfluorocarbon liquid (PFCL) is used to confine the aqueous environment to the anterior vitreous cavity and triamcinolone is ...

This report reviews current knowledge of the ultrastructural features of the vitreoretinal juncture in its normal state, in eyes with posterior vitreous detachment (PVD), and in eyes with epiretinal membranes (ERM's) and then presents new concepts concerning the interrelationship of ERM's and the vitreous. Results show no vitreous residues on retinal surface following uncomplicated rhegmatogeno...

The role of extravascular coagulation in vitreous membrane formation was investigated in rabbits and owl monkeys. Eyes injected with platelet-poor plasma did not develop vitreous membranes. In contrast, the injection of platelet-rich plasma and gel-filtered platelet preparations into the vitreous cavity resulted in immediate membrane formation. These vitreous membranes were only slowly and inco...

Multiple rheological studies have characterized the dynamic material properties of adult vitreous, but no studies have investigated vitreous properties in the immature eye. In this study, premature, infant and adult ovine vitreous specimens were tested in shear to identify differences in dynamic moduli with age. Significant inertial artifact and rapid degradation of the vitreous ex vivo hindere...

BACKGROUND During eye rotations the vitreous humour moves with respect to the eye globe. This relative motion has been suggested to possibly have an important role in inducing degradation of the gel structure, which might lead to vitreous liquefaction and/or posterior vitreous detachment. Aim of the present work is to study the characteristics of vitreous motion induced by eye rotations. METH...

OBJECTIVE To evaluate the expression of connective tissue growth factor (CTGF) and its fragments in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to localize CTGF expression in associated preretinal membranes. RESEARCH DESIGN AND METHODS Vitreous was obtained from 24 patients with active PDR, 4 patients with quiescent PDR, and 23 patients with other retinal diseas...

Imaging the vitreous is an attempt to view what is by design invisible. The inability to adequately image vitreous hinders a more complete understanding of its normal structure and function and how these change in aging and disease. The combined use of more than one technique could provide better imaging for investigational and clinical purposes. Past and present imaging methodologies are summa...

AIMS The vitreous levels of soluble intercellular adhesion molecule 1 (sICAM-1) were investigated in uveitic eyes undergoing vitrectomy for retinal detachment (RD) or other complications, and the presence of this molecule was related to disease activity and vitreous levels of the cytokine tumour necrosis factor alpha (TNF alpha), known to upregulate ICAM-1 expression on various cells. METHODS...

PURPOSE To determine the chronology of the appearance and localization of hyaluronic acid (HA) in mouse vitreous during the embryonic and early postnatal stages of development and in human vitreous during early embryonic development. METHODS A histochemical method using the specific affinity for HA of a bovine cartilage proteoglycan was used on mouse eyes at embryonic (11 to 18 days) and earl...

Vitreous samples were obtained from 41 eyes undergoing vitrectomy, and radioimmunoassays were performed to measure concentrations of the prostaglandins PGE2, PGF2 alpha, prostacyclin, and thromboxane. Presumably physiological levels (approximately 100 picograms/ml) were found in vitreous from eyes undergoing cataract extraction. Eyes with vitreous haemorrhage, retinal detachment, or cystoid mac...