Nutritional deficiencies are frequent in malaria-endemic areas. It seems that micronutrient antioxidants play an important role in malaria parasite's proliferation. Thus, the effect of vitamin C deficiency on malaria infection was examined in mice. When vitamin C deficient mice, L-gulono-gamma-lactone oxidase gene knockout mice which are unable to synthesize ascorbic acid, were infected with a ...

Vitamin B12 (B12) deficiency has been linked to developmental disorders, metabolic abnormalities, and neuropathy; however, the mechanisms involved remain poorly understood. Caenorhabditis elegans grown under B12-deficient conditions for five generations develop severe B12 deficiency associated with various phenotypes that include decreased egg-laying capacity (infertility), prolonged life cycle...

conclusions the used protocol is not enough for treating vitamin d deficiency. furthermore, the protocol should be revised according to baseline vitamin d classification. results after initial evaluation, 116 cases were found to be deficient, and were divided into two equal groups of 58. no significant difference was found between the normal, treated and non-treated groups regarding age and gen...

BACKGROUND Glutathione S-transferases (GSTs) are detoxifying enzymes that contribute to the glutathione-ascorbic acid (vitamin C) antioxidant cycle. OBJECTIVE The objective was to determine whether GST genotypes modify the association between dietary vitamin C and serum ascorbic acid. DESIGN Nonsmoking men and women (n = 905) between 20 and 29 y of age were participants in the Toronto Nutri...

OBJECTIVES Epidemiological studies have reported that vitamin D deficiency is associated with inflammatory disease. Smoking is a well-known risk factor for inflammation. However, few studies have investigated the interactive effect of vitamin D deficiency and smoking on inflammation. This study aims to investigate the interaction of vitamin D and smoking with inflammatory markers in the urban e...

Vitamin C deficiency causes scurvy and can compromise many bodily functions. Vitamin C is involved in mast cells and other immune cells, such as NK cells, and differentiation of Th0 subset into Th1 cells. In addition, vitamin C has an important effect on p38 MAPK pathway and NF-kappa activity. Vitamin C is an anti-oxidant which protects the immune cells against intracellular ROS generated in al...

Objective : To study the relationship between vitamin C and the severity of periodontitis Materials and Methods : The study population consis ted of subjects from the Malabar/Purbasari tea estate on West Java, Indonesia. In 2002, clinical measurements were performed in 128 subjects, including evaluation of plaque, bleeding on probing, pocket depth and attachment loss. In 2005, 123 out of 128 su...