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An Escherichia coli mutant with a disrupted visA gene was defective in ferrochelatase activity but expressed wild-type levels of protoporphyrinogen oxidase activity. The visA coding region was placed under the transcriptional control of T7 RNA polymerase in an E. coli expression system, and the product was expressed as a 38-kDa protein. The overexpressed protein was purified to near homogeneity...
Pancreatic cancer is an aggressive malignancy with morbidity rates almost equal to mortality rates because of the current lack of effective treatment options. Here, we describe a targeted approach to treating pancreatic cancer with effective therapeutic efficacy and safety in noninvasive imaging models. We developed a versatile expression vector "VISA" (VP16-GAL4-WPRE integrated systemic amplif...
نامه به سردبیراستافیلوکوکوس اورئوس به‌عنوان یکی از مهم‌ترین عوامل بیماری‌زای انسانی محسوب می‌شود [1]. با ظهور سویه‌های مقاوم به متی‌سیلینِ استافیلوکوکوس اورئوس (MRSA) در دهه‌ی 1960 و شیوع آن در دو دهه بعد، ونکومایسین به‌عنوان اولین خط درمان عفونت‌های ناشی از این سویه‌ها مورد استفاده قرار گرفت [2]. در سال 1997، Hiramatsu و همکارانش اولین سویه MRSA با حساسیت متوسط نسبت به ونکومایسین (VISA) و حداقل...
Intermediate (VISA-type) vancomycin resistance in Staphylococcus aureus has been associated with a range of physiologic and genetic alterations. Previous work described the emergence of VISA-type resistance in two clonally-distinct series of isolates. In both series (the first belonging to MRSA clone ST8-USA300, and the second to ST5-USA100), resistance was conferred by a single mutation in yvq...
ME1036, a novel parenteral carbapenem, was developed for the treatment of meticillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). A model of haematogenous pulmonary infection was induced in mice by tail vein injection of MRSA strain NUMR101 or VISA Mu50 enmeshed in agar beads. After 24h of infection, mice were treated twice daily for 7 days with 200mg/kg/...
This study evaluated the effect of acetazolamide on thyroid-associated ophthalmopathy (TAO). Patients with a VISA classification index equal to or more than four were enrolled in the study and were randomly assigned into two groups. In both groups, treatment was initiated using prednisolone. Patients in the case group received acetazolamide tablets 250 mg daily in addition to prednisolone. Thre...
Prolonged vancomycin usage may cause methicillin-resistant Staphylococcus aureus to become vancomycin-intermediate S. aureus (VISA) and heterogeneous VISA (hVISA). Mechanisms of vancomycin resistance of VISA and hVISA are still unclear. In this study, analyses of nucleotide sequence variations in 30 vancomycin-sensitive S. aureus (VSSA), 41 hVISA and 16 VISA isolates revealed 29 single-nucleoti...
BACKGROUND There is increasing frequency of vancomycin-intermediate and -resistant Staphylococcus aureus (VISA and VRSA) isolates identified in clinical practice. There are limited reports evaluating susceptibility patterns and molecular characteristics of these strains. METHODS Laboratory analysis was performed on 13 VRSA and 33 VISA isolates, including susceptibility testing by broth microd...
We introduce an end-to-end framework for data quality that integrates business strategy, data quality models, and supporting investigative and governance processes. We also describe a supporting IT architecture for this framework. Finally, we describe how this framework was implemented at Visa International Service Association (“Visa”) and some of the lessons learned during its use over the pas...
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