BACKGROUND Previous studies have demonstrated that DC differentially regulate influenza A virus (IAV)-specific CD8 T cell responses in vivo during high and low dose IAV infections. Furthermore, in vitro infection of DC with IAV at low versus high multiplicities of infection (MOI) results in altered cytokine production and a reduced ability to prime naïve CD8 T cell responses. Flow cytometric de...

During the SARS-CoV-2 global pandemic, several vaccines, including mRNA and adenovirus vector approaches, have received emergency or full approval. However, supply chain logistics hampered vaccine delivery, which is impacting mass vaccination strategies. Recent studies identified different strategies for dose administration so that constraints issues are diminished. These include increasing tim...

BACKGROUND/AIMS To assess the durability of protective hepatitis B surface antibody (anti-HBs) titers in HIV-infected patients who responded to double-dose hepatitis B virus (HBV) rescue vaccination. METHODS A retrospective chart review was performed for HIV-infected patients who received the double-dose HBV rescue vaccination at 0-, 1-, and 2-month intervals after they had failed conventiona...

High-Dose Ribavirin Enhances Early Virological Response in Hepatitis C Genotype 1Infected Patients. Lindahl K1, Hörnfeld E, Ståhle L, Carlsson T, Weiland O, Parke Å, Schvarcz R. Ther Drug Monit. 2015 Dec;37(6):745-50. doi: 10.1097/FTD.0000000000000210. BACKGROUND: The aim of the study was to investigate whether patients with a previous nonresponse to standard of care treatment with ribavirin do...

aim : the aim of this study was to identify and compare the pattern of acute viral hepatitis in two regions of iran. background : the epidemiological pattern of acute hepatitis varies across the globe depending on geographic region, health status, socioeconomic conditions and differences in exposure to etiological factors. patients and methods : a cross-sectional study was carried out among 357...

measles is one of the viral and extremely contagious and acute diseases of childhood affecting almost all children. prior to the discovery of the measles vaccine, the mortality from this disease was one of the highest child mortality figures, especially in the developing countries, with the death rate ranging over 5 to 10% of the infected? before the vaccination program i was launched in the co...

BACKGROUND A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4(+) T cells of treated, aviremic human immunodeficiency virus (HIV)-positive participants. The ability of multiple exposures to VOR to repeatedly disrupt latency has not been directly measured, to our knowledge. METHODS Five participants in whom resting CD4(+) T-cel...

To protect against dengue viral infection, a novel lipidated dengue subunit vaccine was rationally designed to contain the consensus amino acid sequences derived from four serotypes of dengue viruses. We found that the lipidated consensus dengue virus envelope protein domain III (LcED III) is capable of activating antigen-presenting cells and enhancing cellular and humoral immune responses. A s...

context several risk factors play the role in the development of hepatocellular carcinoma (hcc) from which chronic hepatitis b and c infections are the most important ones. dna integration of hepatitis viruses alters the function of critical genes promoting malignant transformation of virus-infected liver cells. evidence acquisition there are remarkable geographic differences in prevalence of c...