Differential toxicity of vincristine and vinblastine against cells of a cloned subline of human promyelocytic leukemia (HL-60/Cl) was dependent on exposure conditions. During continuous exposures of 48 h, vincristine and vinblastine were equitoxic with drug concentrations that inhibited proliferation rates by 50% of 7.6 and 8.1 nM, respectively. When cells were subjected to 4-h exposures and tr...

Neurological adverse effects are known to complicate vincristine treatment. In occasional reports of bowel and bladder disturbance it has not been possible to incriminate autonomic neuropathy. We report here three patients with symptoms and signs which could be ascribed to vincristine-induced autonomic neuropathy. Case Reports Case 1.-A 75-year-old man presented with recurrent Hodgkin's disease...

BACKGROUND Catharanthus roseus, a medicinal plant, is known to produce secondary metabolites, vincristine and vinblastine, which are terpenoid indole alkaloids. Previously we have reported that Eutypella spp - CrP14 isolated from stem cutting of this plant had shown significant antiproliferative activity when tested in vitro against HeLa cell line. The present study was conducted to identify th...

Background: Vincristine polyneuropathy is a major neurotoxic complication of treatment for acute lymphoblastic leukemia in children. A close relationship between genetic variants candidate genes associated with the vincristine neurotoxicity various ethnic groups has been proposed. Therefore, identification risk factors underlying predisposition to could allow development effective tools prevent...

Catharanthus roseus L. is an important medicinal plant producing several terpenoid indole alkaloids (TIAs) such as vincristine and vinblastine secondary metabolites with anticancer activity. The TIAs biosynthetic pathways are affected by biotic and abiotic stresses. In this study the effect of drought (7 days), salinity (150 mM NaCl), foliar spray of salicylic acid (10-5 M) and salicylic acid i...

Satureja khuzestanica Jamzad (Marzeh Khuzestani in Persian) is an endemic plant that iswidely distributed in the southern part of Iran. Despite the number of papers published on thisplant, no one has focused on its anticancer effects. Therefore, the present study was designedto investigate the selective cytotoxic and anti-proliferative properties of satureja khuzestanicatotal extract (SKE). MCF...

Satureja khuzestanica Jamzad (Marzeh Khuzestani in Persian) is an endemic plant that iswidely distributed in the southern part of Iran. Despite the number of papers published on thisplant, no one has focused on its anticancer effects. Therefore, the present study was designedto investigate the selective cytotoxic and anti-proliferative properties of satureja khuzestanicatotal extract (SKE). MCF...

Axon degeneration is a prominent feature of various neurodegenerative diseases, such as Parkinson's and Alzheimer's, and is often characterized by aberrant mitochondrial dynamics. Mitochondrial fission, fusion, and motility have been shown to be particularly important in progressive neurodegeneration. Thus we investigated these imperative dynamics, as well as mitochondrial fragmentation in vinc...

Drugs which are used in chemotherapy to cure cancer, generated destruction effects in sensitive of organs as testies. These substances are disrupted Spermatogenesis. The aim of this Study is investigating protective effects of cetrorelix from side effects of Vincristine. 30 adult male mice were divided into 3 equal groups as: control, vincristine (V) and vincristine + cetrorelix (V+C) groups. A...

OBJECTIVES/HYPOTHESIS A new treatment for acute unilateral vocal-fold paralysis (UVFP) was proposed in which a drug is injected into the posterior cricoarytenoid muscle (PCA) shortly after nerve injury, before the degree of natural recovery is known, to prevent antagonistic synkinetic reinnervation. This concept was tested in a series of canine experiments using vincristine as the blocking agen...