نتایج جستجو برای: viii deficiency

تعداد نتایج: 157622  

Journal: :Blood 1974
C F Abildgaard J Harrison

Eight of 1 1 children of a known Fletcher taming celite or kaolin were sensitive to factor-deficient individual were found to Fletcher factor deficiency, while one rehave normal activated partial thromboagent containing ellagic acid did not deplastin times, normal levels of factors VIII, tect this abnormality. The finding of an IX, Xl, and XII, and a mean Fletcher factor abnormal partial thromb...

Journal: :Annals of the Academy of Medicine, Singapore 2009
Chieh Suai Tan Kenneth P Chan Charles T Chuah Heng Joo Ng Foong Koon Cheah Felicia S Teo Philip C T Eng

Dear Editor, Acquired Factor VIII (FVIII) deficiency is a rare disorder occurring at a rate of approximately 1 person per million each year.1 It is due to the spontaneous development of auto-antibodies against FVIII. In 50% of the cases, no cause is identified, although it can be associated with pregnancy, autoimmune disease and malignancy.1 Inhibition of FVIII occurs and patients may present w...

Background: Plasma medicine is an innovative and emerging field used in a broad range of medical conditions. Objective: The present study focused on consumption, documentation pattern and traceability of plasma-derived medicines in a teaching and referral hospital. Method: A two-step study was conducted from October to December 2015. During the first phase, the patient records receiving plasm...

Background: Plasma medicine is an innovative and emerging field used in a broad range of medical conditions. Objective: The present study focused on consumption, documentation pattern and traceability of plasma-derived medicines in a teaching and referral hospital. Method: A two-step study was conducted from October to December 2015. During the first phase, the patient records receiving plasm...

Journal: :World Journal of Biology Pharmacy and Health Sciences 2023

Hemophilia A is an inherited bleeding disorder caused by deficiency of coagulation factor VIII. It transmitted in X-linked recessive pattern from female carriers to male children. We report the observation a severe hemophilia newborn with history siblings who present hemarthrosis left elbow. The diagnosis was suspected and confirmed through biologic investigations imaging. Therefore, patient pu...

2014
Janice M Staber Molly J Pollpeter Angela Arensdorf Patrick L Sinn D Thomas Rutkowski Paul B McCray

Hemophilia A, caused by a deficiency in factor VIII (FVIII), is the most severe inherited bleeding disorder. Hemophilia A is an attractive gene therapy candidate because even small increases in FVIII levels will positively alter the phenotype. While several vectors are under investigation, gene addition from an integrated transgene offers the possibility of long term expression. We engineered t...

Journal: :AJNR. American journal of neuroradiology 2000
A Reeves M Edwards-Brown

We present an unusual case of an intraosseous hematoma in a newborn with a known bleeding disorder. This cephalohematoma was diagnosed shortly after birth, was entirely within the bony skull, and was in fact determined to be an intraosseous hematoma. The initial CT scans showed the unusual appearance and location of the lesion; later scans showed a significant amount of remodeling, with resolut...

Journal: :Research results in pharmacology 2022

Introduction: Ligands of adenosine A1Rs are potential candidates for the development drugs treatment paroxysmal supraventricular tachycardia, angina pectoris, hypertriglyceridemia, type 2 diabetes mellitus, neuropathic pain, and heart failure. At same time, there is a deficiency that can regulate functions A1 receptors. A number A1-antagonists at various stages clinical trials; other not very s...

بوالحسنی, اعظم, سید میکائیلی, افسانه, نصوحی, نیکو,

Background and purpose: Hemophilia is a hereditary X-linked disorder. Females are carriers and males have the disorder. Hemophilia A is caused by deficiency in the production of factor VIII. In some hemophilia patients, inhibitors including IgG1 and IgG4 antibodies are expressed against this factor. These inhibitors interact with factor VIII and suppress its function. The current study aimed at...

Faranoush , Mohammad , Karimi , Katayoun , Managhchi , Mohammad-Reza , Rezaiei–Hemami , Mohsen , Roushan , Nader , Toogeh , Gholamreza , Zarrabi , Fariba ,

Background: The development of inhibitors is a complication factor replacement therapy in hereditary factor VIII deficiency. Several management options are available for the treatment of inhibitor. Rituximab, a monoclonal antibody against CD20, reduces inhibitor level in rare bleeding disorders. The aim of this study was to evaluate the effectiveness of rituximab in lowering or eliminating the ...

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