Inducibility of sustained ventricular tachycardia (VT) and ventricular fibrillation (VF) by programmed ventricular stimulation following acute hypokalemia was studied in 21 anesthetized dogs free of inducible ventricular tachyarrhythmias at baseline. The control mean serum potassium concentration of 3.65 mEq/L was decreased to 2.14 mEq/L by insulin and furosemide administration. Inducibility of...

OBJECTIVE Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-1 receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h p...

OBJECTIVES Evaluation of the laryngeal adductor reflex (LAR) entails delivering air through an endoscope positioned 1 to 2 mm from the arytenoid mucosa to elicit bilateral vocal fold (VF) closure. This short working distance limits visualization to only the ipsilateral arytenoid and results in quantification of a single LAR metric: threshold pressure that evokes the LAR. Our goal was to evolve ...

We sought to develop individual-level Early Warning Indicators (EWI) of virologic failure (VF) for clinicians to use during routine care complementing WHO population-level EWI. A case-control study was conducted at a Durban clinic. Patients after ≥ 5 months of first-line antiretroviral therapy (ART) were defined as cases if they had VF [HIV-1 viral load (VL)>1000 copies/mL] and controls (2:1) i...

Sudden cardiac arrest is most often due to ventricular fibrillation (VF). When no cause found during diagnostic follow-up, classified as idiopathic VF. We hypothesize that subtle repolarization abnormalities may predispose VF, but cannot be detected from the 12-lead electrocardiogram (ECG). To study presence of time (RT) gradients in patients with VF using ECG and noninvasive electrocardiograph...

Purpose Therapeutic prostate-specific antigen (PSA) –targeted poxviral vaccines for prostate cancer have been well tolerated. PROSTVAC-VF treatment was evaluated for safety and for prolongation of progression-free survival (PFS) and overall survival (OS) in a randomized, controlled, and blinded phase II study. Patients and Methods In total, 125 patients were randomly assigned in a multicenter t...

The elution order of 209 polychlorinated biphenyls (PCBs) was determined using five types commercially available capillary columns (VF-Xms, Rtx-20, VF-35ms, VF-1301ms and VF-200ms). In addition, the interference among molecular ion peaks PCDDs non-dioxin like PCB congeners, which affect during dioxin analysis by GC/MS, clarified.

Although a relationship between S-T alternans and life-threatening arrhythmia has been recognized, the mechanism is poorly understood. We examine the role of S-T alternans in the occurrence of ventricular fibrillation (VF) after reperfusion. The left anterior descending coronary artery was occluded for 20 min and then abruptly reperfused in 12 intravenously anesthetized open-chest dogs. Sixty u...

objective(s) this study aimed to examine whether acetyl-l-carnitine (alc) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. materials and methods the isolated hearts were mounted on a langendorff apparatus then perfused by a modified krebs-henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched kreb...