Herpes simplex virus 1 (HSV-1) causes herpes stromal keratitis (HSK), a sight-threatening disease of the cornea for which no vaccine exists. A replication-defective, HSV-1 prototype vaccine bearing deletions in the genes encoding ICP8 and the virion host shutoff (vhs) protein reduces HSV-1 replication and disease in a mouse model of HSK. Here we demonstrate that combining deletion of ICP8 and v...

PURPOSE To use high-spatial-resolution magnetic resonance (MR) imaging to analyze the trabecular bone structure of the calcaneus in patients before and after heart transplantation and to compare this technique with bone mineral density (BMD) measurement in predicting therapy-induced bone loss and vertebral fracture status. MATERIALS AND METHODS High-spatial-resolution 1.5-T MR imaging of the ...

Based on the random phase approximation calculation in two-orbital honeycomb lattice model, we investigate pairing symmetry of Ni-based transition-metal trichalcogenides by electron doping access to type-II van Hove singularities (vHs). We find that chiral even-parity d + id-wave (Eg) state is suppressed odd-parity p ip-wave (Eu) when approaches vHs. The vHs peak density states (DOS) enables st...

This study compared the effect of general anesthesia or regional vertebral analgesia (subarachnoid or epidural) on postoperative cognitive function in 60 young adult (group A) and 60 elderly (group E) patients undergoing orthopedic and urologic surgery. Wechsler Adult Intelligence Scale-Revised for cognitive functions assessment was done preoperatively, and postoperatively; one day and three da...

As science technology grows, medical application is becoming more complex to solve the physiological problems within expected time. Workflow management systems (WMS) in Grid computing are promising solution to solve the sophisticated problem such as genomic analysis, drug discovery, disease identification, etc. Although existing WMS can provide basic management functionality in Grid environment...

Herpes simplex virus 1 (HSV-1) encodes an endoribonuclease that is responsible for the shutoff of host protein synthesis [virion host shutoff (VHS)-RNase]. The VHS-RNase released into cells during infection targets differentially four classes of mRNAs. Thus, (a) VHS-RNase degrades stable cellular mRNAs and α (immediate early) viral mRNAs; (b) it stabilizes host stress response mRNAs after deade...

Humans and mice lacking the interferon signaling molecule Stat1 are sensitive to a variety of pathogens due to their presumed inability to mount a strong innate immune response. The herpes simplex virus type 1 (HSV-1) virion host shutoff (vhs) protein is a multifunctional immunomodulator that counteracts the innate immune response and viruses lacking vhs are attenuated and effective live vaccin...

This special issue of The European Journal of Control is dedicated to some of the results of the European Community Esprit LTR Project VHS Veri cation of Hybrid Systems It consists of papers dealing with various aspects of one of the case studies treated in the project the Experimental Batch Plant at the university of Dortmund Before presenting the papers themselves it is worthwhile to say some...

In the plumes of Hall thrusters and ion thrusters, high energy neutral atoms are created as a result of the charge exchange interaction between exhaust ions and neutral atoms exiting the discharge region. Proper modeling of fast atoms is important for assessing spacecraft-plume interaction in space as well as facility interactions for ground tests. Many numerical models for Hall thrusters appro...