keratoacanthoma (ka) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics  squamous cell carcinoma (scc). essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive scc. the clinical behavior of ka is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanth...

Functional and aesthetical reconstruction, especially of the upper lip after ablative tumor surgery, can be very challenging. The skin of the lip might be sufficiently reconstructed by transpositional flaps from the nasolabial or facial area. Large defects of the lip mucosa, including the vestibule, are even more challenging due to the fact that flaps from the inner lining of the oral cavity of...

The use of eye-color mutants and their corresponding genes as scorable marker systems has facilitated the development of transformation technology in Drosophila and other insects. In the red flour beetle, Tribolium castaneum, the only currently available system for germline transformation employs the exogenous marker gene, EGFP, driven by an eye-specific promoter. To exploit the advantages offe...

Bilateral cleft lip repairs can result in various secondary deformities. One more commonly seen deformity, the whistle deformity, is characterized by a reduced or absent tubercle, orbicularis muscle diastasis, and abnormalities of the philtrum with notched appearance of cupid's bow. Various techniques have been described to address these problems. One common procedure is the lip-switch flap ori...

Stevens-Johnson syndrome (SJS) is a mucocutaneous disorder induced by an immune-complex-mediated hypersensitivity reaction. Nearly half of cases are caused by a reaction to drugs or appear during viral infections and malignancies. A very few cases are caused by a bacterial infection (Streptococcus) or Mycoplasma pneumoniae. Graft versus host disease is another well-established cause, independen...

Exfoliative cheilitis (EC) is an uncommon condition affecting the vermilion zone of the upper, lower, or both lips. EC is characterized by the persistent production and desquamation of thick scales of keratin and flaking of the vermillion border. When removed, these scales leave a normal appearing lip underneath. Although the precise etiology of EC remains unclear, factors such as stress, perso...

Recently five patients with an Albright hereditary osteodystrophy (AHO)-like phenotype were reported to have a subtelomeric deletion of the long arm of chromosome 2. These patients showed a striking resemblance to a number of patients from a large pedigree known to us for a long time. After molecular confirmation of a subtelomeric deletion in one patient, FISH analysis was used and a cryptic tr...