Abstract Background Brachial plexus block has substituted general anesthesia in the majority of patients planned for upper limb surgeries as it avoids undesired effects medications used well stress response associated with airway manipulation. Opioid agonist–antagonists such nalbuphine are adjuvant to improve anesthetic properties bupivacaine. Verapamil an additive effect brachial blockade form...

Verapamil is the first-line preventive medication for cluster headache, an excruciating disorder with strong circadian features. Whereas second- and third-line preventives include known modulators, such as melatonin, corticosteroids, lithium, effects of verapamil are poorly understood. Here, we characterize features using both in vitro vivo models. In Per2::LucSV reporter fibroblasts, treatment...

OBJECTIVE Gelatinases are a large group of proteolytic enzymes that belong to the matrix metalloproteinases (MMPs). MMPs are a broad family of peptidases, which proteolyse the extracellular matrix and have an important role in inflammation. Verapamil is a calcium channel blocker extensively used in the treatment of numerous cardiovascular diseases such as arrhythmia and hypertension. The anti-t...

The effects of verapamil on the intracellular pharmacokinetics of daunorubicin (DNR) in blast cells from the bone marrows of patients with acute nonlymphocytic leukemia (ANLL) were studied to determine whether verapamil was capable of enhancing intracellular accumulation and retention of DNR in ANLL, as has been observed in murine P388 cells resistant to DNR. Seventeen marrows from ANLL patient...

Verapamil inhibition of CYP3A activity results in many drug-drug interactions with CYP3A substrates, but the mechanism of inhibition is unclear. The present study showed that verapamil enantiomers and their major metabolites [norverapamil and N-desalkylverapamil (D617)] inhibited CYP3A in a time- and concentration-dependent manner by using pooled human liver microsomes and the cDNA-expressed CY...

The effect of verapamil on normal sodium (Na)-dependent and slow calcium (Ca)-dependent action potentials recorded from canine cardiac Purkinje fibers was studied. The Ca-dependent slow response was obtained in fibers exposed to solutions in which all NaCl was replaced by tetraethylammonium chloride and in which Ca ranged from 4 mM to 16.2 mM. Verapamil (0.25-2 mg/liter) had little or no effect...

We evaluated the significance of the interaction between rifampin and verapamil in six volunteers who received single doses of verapamil, 10 mg intravenously (IV), then 120 mg orally two days later. Subjects were then given rifampin, 600 mg orally every day for 15 days. After 13 and 15 days of rifampin therapy, the IV and oral doses of verapamil were repeated. Electrocardiograms (ECG) were done...

In past years, the canonical Wnt/β-catenin signaling pathway has emerged as a critical regulator of cartilage development and homeostasis. FRZB, a soluble antagonist of Wnt signaling, has been studied in osteoarthritis (OA) animal models and OA patients as a modulator of Wnt signaling. We screened for FDA-approved drugs that induce FRZB expression and suppress Wnt/β-catenin signaling. We found ...

The effect of verapamil on normal sodium (Na)-dependent and slow calcium (Ca)-dependent action potentials recorded from canine cardiac Purkinje fibers was studied. The Ca-dependent slow response was obtained in fibers exposed to solutions in which all NaCl was replaced by tetraethylammonium chloride and in which Ca ranged from 4 mM to 16.2 mM. Verapamil (0.25-2 mg/liter) had little or no effect...

We conducted a systematic review of all published randomized, controlled trials to assess the risk of cancer or death in patients receiving verapamil for hypertension, angina pectoris, or cardiac arrhythmias. Meta-analysis comparing the risk of new cancers, cancer deaths, and all deaths was performed. Thirty-nine trials comprising 11,201 patients were eligible. Study durations ranged from 8 day...